PMID: 5541231Jan 23, 1971

Insulin antagonist of pituitary origin in plasma of normal and diabetic subjects

British Medical Journal
P ZimmetH P Taft

Abstract

Studies on ultrafiltrates of the plasma of normal and diabetic subjects have shown that a polypeptide of similar characteristics to the growth-hormone-derived polypeptide In-G is present in higher concentrations in diabetic subjects, thus indicating a possible role in the pathogenesis of diabetes mellitus. The polypeptide is absent from the plasma of hypophysectomized diabetic patients.

Related Concepts

Pathogenic Aspects
Insulin Antagonists
Pathogenesis
Pituitary Diseases
Pituitary Hormonal Agents
Diabetes, Autoimmune
Pituitary hormone preparation
Pituitary Gland
Diabetes Mellitus
Pituitary Hormone Suppressant

Related Feeds

Autoimmune Diabetes & Tolerance

Patients with type I diabetes lack insulin-producing beta cells due to the loss of immunological tolerance and autoimmune disease. Discover the latest research on targeting tolerance to prevent diabetes.