PMID: 517645Dec 1, 1979Paper

Insulin antagonistic effects of epinephrine and glucagon in the dog

The American Journal of Physiology
L SaccàRobert S Sherwin

Abstract

The effect of glucagon and/or epinephrine on the response to physiologic insulin infusion was evaluated in dogs. Insulin alone produced a transient fall (50%) in glucose output, a threefold rise in glucose clearance, and a decline in plasma glucose, which then stabilized (40--45 mg/dl) afer 1 h. Glucagon infusion prevented the fall in glucose output, but had no effect on insulin-induced elevations in glucose clearance. The fall in plasma glucose was delayed (20 min), but late hypoglycemia was unaltered. Epinephrine infusion blocked the fall in glucose output as well as the insulin-induced rise in glucose clearance and uptake. Thus, while epinephrine and glucagon were equally effective in preventing the fall in glucose output induced by insulin, epinephrine was more effective in preventing insulin-induced hypoglycemia by virtue of its direct inhibitory action on insulin-stimulated glucose utilization. Simultaneous addition of glucagon and epinephrine increased glucose output twofold, suppressed glucose clearance, and caused a 15--30 mg/dl increase in plasma glucose despite ongoing hyperinsulinemia. Our data thus indicate that synergistic hormone interactions may play a role in the counterregulation of insulin hypoglycemia.

References

Jul 1, 1978·Metabolism: Clinical and Experimental·A D CherringtonM S Harris
Feb 26, 1976·The New England Journal of Medicine·R S SherwinP Felig
Jan 1, 1974·The Journal of Clinical Endocrinology and Metabolism·J E GerichP H Forsham
May 1, 1974·The Journal of Clinical Investigation·R S SherwinR Andres
Apr 1, 1971·Metabolism: Clinical and Experimental·J S Cowan, G Hetenyi
Aug 1, 1960·The American Journal of Physiology·M S HERMAN, E R RAMEY
Sep 25, 1959·Annals of the New York Academy of Sciences·R STEELE

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