Insulin aspart: a review of its use in the management of type 1 or 2 diabetes mellitus

Drugs
Neil A Reynolds, Antona J Wagstaff

Abstract

Insulin aspart (NovoRapid, NovoLog) is a short-acting insulin analogue, which has a faster onset and shorter duration of action than regular human insulin. Insulin aspart administered immediately before meals provided significantly greater improvements in glycosylated haemoglobin and better postprandial glycaemic control than regular human insulin administered 30 minutes before meals, when used in a basal-bolus regimen with neutral protamine Hagedorn (NPH) insulin, in randomised, nonblind studies in patients with type 1 diabetes mellitus. In patients with type 2 diabetes, insulin aspart provided similar glycaemic control to regular human insulin, administered in a basal-bolus regimen with NPH insulin. Small studies suggest that the use of insulin aspart in combination with oral hypoglycaemic agents may be beneficial. Insulin aspart, administered by continuous subcutaneous insulin infusion (CSII) provided better glycaemic control than insulin aspart multiple daily injection regimens in patients with type 1 (but not type 2) diabetes, and had similar efficacy to CSII with insulin lispro or regular human insulin in type 1 diabetes. Limited studies show insulin aspart to be effective in children, adolescents and young adults with ty...Continue Reading

References

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Citations

Jun 27, 2007·Diabetes, Obesity & Metabolism·T ParknerJ S Christiansen
Apr 29, 2008·Arquivos brasileiros de endocrinologia e metabologia·Antonio Carlos Pires, Antonio Roberto Chacra
Jan 30, 2009·Basic & Clinical Pharmacology & Toxicology·Rannveig Linda ThorisdottirJens Sandahl Christiansen
Mar 13, 2014·Pediatric Annals·Steven Ghanny, Javier Aisenberg
Jun 2, 2009·Archives of Physiology and Biochemistry·Ashish ShuklaDoris Mayer
May 1, 2008·Diabetic Medicine : a Journal of the British Diabetic Association·T ParknerJ S Christiansen
Jan 19, 2010·Current Medical Research and Opinion·Etie S Moghissi
Apr 11, 2017·Angewandte Chemie·Kenta AraiMichio Iwaoka
Sep 4, 2015·Diabetic Medicine : a Journal of the British Diabetic Association·S M SildorfUNKNOWN Danish Study Group of Diabetes in Children
Feb 6, 2008·Diabetes, Obesity & Metabolism·Pedro Iglesias, Juan J Díez

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