Insulin attenuates atrophy of unweighted soleus muscle by amplified inhibition of protein degradation

Metabolism: Clinical and Experimental
M E TischlerE J Henriksen

Abstract

Unweighting atrophy of immature soleus muscle occurs rapidly over the first several days, followed by slower atrophy coinciding with increased sensitivity to insulin of in vitro protein metabolism. This study determined whether this increased sensitivity might account for the diminution of atrophy after 3 days of tall-cast hindlimb suspension. The physiological significance of the increased response to insulin in unweighted muscle was evaluated by analyzing in vivo protein metabolism for day 3 (48 to 72 hours) and day 4 (72 to 96 hours) of unweighting in diabetic animals either injected with insulin or not treated. Soleus from nontreated diabetic animals showed a similar loss of protein during day 3 (-16.2%) and day 4 (-14.5%) of unweighting, whereas muscle from insulin-treated animals showed rapid atrophy (-14.5%) during day 3 only, declining to just -3.1% the next day. Since fractional protein synthesis was similar for both day 3 (8.6%/d) and day 4 (7.0%/d) of unweighting in insulin-treated animals, the reduction in protein loss must be accounted for by a slowing of protein degradation due to circulating insulin. Intramuscular (IM) injection of insulin (600 nmol/L) stimulated in situ protein synthesis similarly in 4-day unwei...Continue Reading

References

Aug 1, 1975·The Biochemical Journal·D J MillwardJ C Waterlow
Dec 1, 1990·Journal of Applied Physiology·C R Kirby, M E Tischler
Jul 1, 1990·Journal of Applied Physiology·D A RileyJ W Mellender
Jan 1, 1990·Journal of Applied Physiology·D B Thomason, F W Booth
Jul 1, 1990·Muscle & Nerve·M E TischlerS B Rosenberg
Aug 1, 1990·Journal of Applied Physiology·D DesplanchesH Hoppeler
Feb 23, 1987·Life Sciences·J M FaganM E Tischler
Jul 1, 1987·Journal of Applied Physiology·D B ThomasonK M Baldwin
Nov 1, 1987·Journal of Applied Physiology·R W TsikaK M Baldwin
Oct 1, 1988·Journal of Applied Physiology·A BonenM H Tan
Mar 1, 1988·Metabolism: Clinical and Experimental·E J Henriksen, M E Tischler
Jul 1, 1987·The Journal of Clinical Investigation·R A Gelfand, E J Barrett
Jul 1, 1987·Journal of Applied Physiology·D B ThomasonK M Baldwin
Jul 1, 1986·Journal of Applied Physiology·P LoughnaD F Goldspink
Jul 1, 1986·Muscle & Nerve·S R Jaspers, M E Tischler
Sep 1, 1986·Pflügers Archiv : European journal of physiology·D F GoldspinkG Goldspink
Jun 1, 1983·Muscle & Nerve·E V Moruzzi, E Bergamini
Nov 1, 1984·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·S R Jaspers, M E Tischler
Nov 1, 1994·Metabolism: Clinical and Experimental·M E Tischler
Dec 1, 1993·Journal of Applied Physiology·S AboudrarD Desplanches
Aug 1, 1993·Journal of Applied Physiology·E J Henriksen, L S Ritter
Apr 1, 1993·Journal of Applied Physiology·E J Henriksen, L S Ritter
Jan 1, 1960·Scandinavian Journal of Clinical and Laboratory Investigation·E RAABO, T C TERKILDSEN

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Citations

Aug 12, 2004·American Journal of Physiology. Endocrinology and Metabolism·James D FluckeyCharlotte A Peterson
Aug 9, 2001·Neurobiology of Disease·J R Singleton, E L Feldman

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