PMID: 6990775Apr 1, 1980Paper

Insulin binding and glucose uptake of adipocytes in rats adapted to hypergravitational force

The American Journal of Physiology
M KobayashiJ Oyama

Abstract

Rats were exposed to 4.15 g for 1 yr and weight and age matched, and lean noncentrifuged rats were used as control groups. Rats exposed to chronic hypergravity (hypergravic rats) were found to show lower ambient insulin levels, greater food intake with smaller body weight gain, and decreased size of isolated adipocytes. The ability of adipocytes from the hypergravic rats to bind insulin was increased. With Scatchard analysis, both number and affinity of receptors were increased. In contrast to the increased binding, glucose transport was found to be decreased in adipocytes from these animals. However, when the data were expressed as a percentage of maximal effect, the half maximal insulin effect for both the hypergravic and lean control groups was produced at an insulin concentration of 0.23 +/- 0.02 ng/ml, which was lower than the insulin concentration of 0.31 +/- 0.02 ng/ml for the weight-matched control group (P less than 0.05). This increased insulin sensitivity in the hypergravic group was accounted for by an increased number of receptors.

References

Jun 1, 1975·Endocrinology·J M Olefsky, G M Reaven
Feb 1, 1978·The Journal of Clinical Investigation·J M Olefsky, M Kobayashi
Jul 1, 1978·The Journal of Clinical Investigation·M Kobayashi, J M Olefsky
Mar 1, 1975·The American Journal of Physiology·B C Daligcon, J Oyama
Oct 27, 1975·Biochemical and Biophysical Research Communications·P De Meyts, J Roth
Jan 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·J R GavinD N Buell
Nov 24, 1972·Biochimica Et Biophysica Acta·J GliemannS Gammeltoft
Aug 17, 1973·Biochimica Et Biophysica Acta·S Gammeltoft, J Gliemann
Nov 1, 1971·The Journal of Clinical Endocrinology and Metabolism·B Desbuquois, G D Aurbach
Sep 1, 1971·The American Journal of Physiology·M Di GirolamoJ W Fertig
Apr 16, 1971·Biochemical and Biophysical Research Communications·P FreychetD M Neville

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Citations

Aug 19, 2003·Journal of Applied Physiology·K PlautA E Ronca

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