PMID: 7030405Nov 18, 1981Paper

Insulin binding and internalization in rat hepatocytes during prenatal and postnatal life

Biochimica Et Biophysica Acta
F AutuoriP Luly

Abstract

Insulin binding to isolated rat hepatocytes was studied during prenatal and postnatal life. Results show that in hepatocytes isolated from prenatal, postnatal and adult rat there is a constant increase in the number of insulin binding sites per cell, whereas the affinity of plasma membrane receptors for the hormonal ligand remains unaltered from prenatal to adult hepatocytes. Autoradiographic studies indicate a greater internalization of hormone during prenatal life and, taking into account the increase of cell size, suggest an unchanged surface density of receptor sites before and after birth.

References

Jun 21, 1979·Nature·J L GoldsteinM S Brown
Jun 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·J L CarpentierL Orci
Oct 15, 1979·FEBS Letters·B DesbuquoisA Huet de Froberville
Oct 27, 1975·Biochemical and Biophysical Research Communications·P De Meyts, J Roth

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Citations

Dec 1, 1990·Diabetes/metabolism Reviews·L AertsF A Van Assche
Jan 1, 1988·Mechanisms of Ageing and Development·P BaldiniP Luly
Nov 1, 1990·Mechanisms of Ageing and Development·S LeoniM T Mangiantini
Dec 1, 1983·Archives of Biochemistry and Biophysics·A M Caliendo, M S Patel
Jan 1, 1987·Journal of Cellular Physiology·S LeoniL Conti Devirgiliis
Dec 16, 1988·Biochimica Et Biophysica Acta·S K EricksonA Trentalance
Dec 16, 1988·Biochimica Et Biophysica Acta·F BurgayaI Ramírez
Jul 1, 1986·Molecular and Cellular Endocrinology·P BaldiniP Luly

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