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Insulin deficiency promotes formation of toxic amyloid-β42 conformer co-aggregating with hyper-phosphorylated tau oligomer in an Alzheimer's disease model

Neurobiology of Disease

Jan 14, 2020

Tomohiro ImamuraJun-Ichi Kira

Abstract

The toxic conformer of amyloid β-protein (Aβ) ending at 42 (Aβ42), which contains a unique turn conformation at amino acid residue positions 22 and 23 and tends to form oligomers that are neurotoxic, was reported to play a critical role in the pathomechanisms of Alzheimer's disease (AD)...read more

Mentioned in this Paper

Hippocampus (Brain)
Cerebral Cortex
Injection Procedure
Diabetes Mellitus
glycogen synthase kinase 3 beta
Laboratory mice
Alzheimer's Disease
In Vivo
Insulin Signaling Pathway
Mouse Model
1
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Insulin deficiency promotes formation of toxic amyloid-β42 conformer co-aggregating with hyper-phosphorylated tau oligomer in an Alzheimer's disease model

Neurobiology of Disease

Jan 14, 2020

Tomohiro ImamuraJun-Ichi Kira

PMID: 31927145

DOI: 10.1016/j.nbd.2020.104739

Abstract

The toxic conformer of amyloid β-protein (Aβ) ending at 42 (Aβ42), which contains a unique turn conformation at amino acid residue positions 22 and 23 and tends to form oligomers that are neurotoxic, was reported to play a critical role in the pathomechanisms of Alzheimer's disease (AD)...read more

Mentioned in this Paper

Hippocampus (Brain)
Cerebral Cortex
Injection Procedure
Diabetes Mellitus
glycogen synthase kinase 3 beta
Laboratory mice
Alzheimer's Disease
In Vivo
Insulin Signaling Pathway
Mouse Model
1

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Limbic System

The limbic system is comprised of several different parts of the brain involved in emotion, motivation, learning, and memory. Discover the latest research on the limbic system here.

Tau Toxicity in the Synapses

Tau toxicity has been implicated in the emergence of synaptic dysfunction in Alzheimer's disease. Here is the latest research on Tau Toxicity in the Synapses.

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