Insulin differentially regulates monocyte and polymorphonuclear neutrophil functions in healthy young and elderly humans

The Journal of Clinical Endocrinology and Metabolism
Stéphane WalrandMarie-Paule Vasson

Abstract

Insulin can regulate immune cell function. Aging is associated with various degrees of insulin resistance together with reduced immune cell activity. We investigated the hypothesis that blood monocytes and polymorphonuclear neutrophils (PMNs) are less responsive to the action of insulin in elderly subjects. DESIGN-INTERVENTION: We evaluated the effect of hyperinsulinemia (0.7 mU/kg(-1) fat-free mass per minute(-1)) on monocyte and PMN activity using a 4-h euglycemic clamp technique. Eight young (24 +/- 6 yr old) and nine elderly (69 +/- 4 yr old) healthy volunteers participated in the study. Monocyte and PMN receptor expression and density were measured using flow cytometric detection. PMN chemotaxis toward formyl-Met-Leu-Phe (fMLP) was evaluated using a two-compartment chamber. PMN and monocyte phagocytosis was determined by measuring the engulfment of opsonized particles. Microbicidal functions were determined based on the production of reactive oxygen species (ROS) and bactericidal protein by stimulated cells. The density of PMN and monocyte insulin receptors was not affected by age or insulin clamp treatment regardless of the age. Insulin was able to regulate the expression of receptors involved in PMN action in the young-a...Continue Reading

References

May 1, 1979·The Journal of Clinical Investigation·R DeFronzoV Soman
May 1, 1992·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·F CavalotM Trovati
Oct 1, 1992·Journal of Diabetes and Its Complications·A N Bessman, F L Sapico
Jul 1, 1990·Diabetic Medicine : a Journal of the British Diabetic Association·A CollierB M Frier
Aug 1, 1990·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·D R DavilaK W Kelley
Feb 1, 1990·Clinical Immunology and Immunopathology·B DamtewJ A Marino
Apr 1, 1986·Journal of Leukocyte Biology·J E NagelB S Bender
Mar 25, 1971·The New England Journal of Medicine·A Mowat, J Baum
Aug 1, 1983·The Journal of Clinical Endocrinology and Metabolism·S V ShahS D Eilen
Dec 1, 1984·Annals of Neurology·R DuaraS I Rapoport
Oct 1, 1984·The Journal of Clinical Investigation·J H Helderman
Nov 1, 1984·Mechanisms of Ageing and Development·G J LigthartG G Steinmann
Jul 1, 1981·Mechanisms of Ageing and Development·I D GardnerJ W Lawton
Feb 1, 1993·The Journal of Clinical Investigation·M P Bevilacqua, R M Nelson
Jun 1, 1993·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·F CavalotM Trovati
Jun 1, 1993·Mechanisms of Ageing and Development·C TortorellaS Antonaci
Jul 1, 1997·The American Journal of Clinical Nutrition·G KomakiC Kubo
Aug 1, 1997·The American Journal of Clinical Nutrition·R K Chandra
Mar 14, 1998·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·S M Baumgartner-Parzer, D Tschoepe
Oct 8, 1998·Experimental Gerontology·P C BragaC Vergani
Aug 18, 1999·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·P A Oldenborg
Dec 2, 1999·Immunologic Research·L GinaldiD Quaglino
Jan 5, 2000·Journal of Immunological Methods·C Dahlgren, A Karlsson
Jul 21, 2000·The Journal of Clinical Endocrinology and Metabolism·A KatzM J Quon
Sep 1, 2000·The American Journal of Clinical Nutrition·S WalrandL Cynober
Mar 7, 2001·The Journal of Clinical Endocrinology and Metabolism·A AljadaP Dandona
Jul 13, 2001·Infectious Disease Clinics of North America·H M Calvet, T T Yoshikawa
Aug 21, 2001·Mechanisms of Ageing and Development·J M LordM Salmon
Apr 15, 2003·Clinica Chimica Acta; International Journal of Clinical Chemistry·Stéphane WalrandMarie-Paule Vasson
Apr 26, 2003·Mechanisms of Ageing and Development·Anja Kristina Schröder, Lothar Rink
Sep 4, 2003·Journal of the American Pharmacists Association : JAPhA·Keith Campbell

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Citations

Oct 14, 2008·Rejuvenation Research·Carl F FortinTàmàs Fülöp
Jun 15, 2007·Current Opinion in Clinical Nutrition and Metabolic Care·Philip C CalderPhilip Newsholme
Dec 16, 2011·Veterinary Immunology and Immunopathology·Todd C HolbrookDianne McFarlane
Jun 6, 2014·International Journal of Endocrinology·Fangming XiuMarc G Jeschke
May 6, 2011·Diabetes Care·José María Moreno-Navarrete, José Manuel Fernández-Real
Dec 18, 2008·Journal of Applied Oral Science : Revista FOB·Jônatas Caldeira EstevesIdelmo Rangel Garcia-Júnior
Jul 9, 2009·The Journal of Clinical Endocrinology and Metabolism·J M Moreno-NavarreteJ M Fernández-Real
Oct 30, 2016·Shock·Silvia C TrevelinFernando Q Cunha
Mar 17, 2021·Journal of Leukocyte Biology·Walter David Cruz-PinedaOlga Lilia Garibay-Cerdenares
May 18, 2021·Frontiers in Immunology·Cesare TripolinoFrancesco Ursini
Jun 12, 2021·Immunology·Gustav van NiekerkAnna-Mart Engelbrecht
Jul 25, 2021·Brain, Behavior, and Immunity·Richard J SimpsonKarsten Krüger
Oct 18, 2007·Current Opinion in Endocrinology, Diabetes, and Obesity

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