PMID: 8591698Aug 1, 1995Paper

Insulin doses in children using conventional therapy for insulin dependent diabetes

Diabetes Research and Clinical Practice
N KerouzM J MacDonald

Abstract

The objective of this project was to develop plots of daily insulin dosages by percentile in diabetic children and to analyze various factors, such as metabolic control, age, and duration of diabetes that might influence the insulin prescription. Patients in extremely poor metabolic control (HbA1C > 9.8%) and patients with less than 1 year of diabetes were excluded from analysis. Patients were aged 2-21 years and the mean age at diagnosis was 8 years. Thirty-two percent of the patients were younger than 5 years and 15% were older than 15 years at diagnosis. Ninety-nine percent of patients used both regular and intermediate-acting (NPH or Lente) insulin 10-30 min before breakfast and again in the evening. Ten percent of the patients used only regular insulin at supper but used intermediate-acting insulin at bedtime. Insulin doses varied between 0.3 and 1.2 U/kg/day in prepubertal children (mean, 0.8 U/kg/day) and 0.5 and 1.8 U/kg body weight/day in pubertal children (mean, 1.25 U/kg/day). Average insulin doses in boys and girls were similar, except at ages 10-13, when the dose was significantly higher in girls. The insulin dose declined after age 17 in both genders to a value at age 21 that was 20-30% lower than the highest dose...Continue Reading

References

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Citations

Oct 27, 2001·Diabetic Medicine : a Journal of the British Diabetic Association·K TylleskärJ Gustafsson
Sep 10, 2005·Journal of Paediatrics and Child Health·Tara BharuchaMargaret Zacharin
Jan 1, 2009·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Amy Fleischman, Erinn T Rhodes
Mar 26, 2008·European Journal of Endocrinology·Susanna WiegandUNKNOWN DPV-Wiss Study Group
Mar 25, 2005·Pediatric Diabetes·Thomas ReinehrUNKNOWN DPV-Wiss Study Group
Aug 21, 2013·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Oindrila RahaRaghavendra Rao Vadlamudi
May 1, 1997·Journal of Pediatric Endocrinology & Metabolism : JPEM·H B Mortensen, P Hougaard
Feb 4, 2014·The Journal of Clinical Endocrinology and Metabolism·Firas H El-KhatibEdward R Damiano
Nov 11, 2008·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Matthew D StephenDon P Wilson

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