Insulin dysregulation in horses with systemic inflammatory response syndrome

Journal of Veterinary Internal Medicine
François-René BertinAllison Jean Stewart

Abstract

Systemic inflammation is a cause of insulin dysregulation in many species, but the insulin and glucose dynamics in adult horses diagnosed with systemic inflammatory response syndrome (SIRS) are poorly documented. In SIRS in horses, insulin and glucose dynamics will be altered and associated with survival. Adult horses diagnosed with SIRS admitted to a referral hospital. Prospective study enrolling horses diagnosed with SIRS in which serum insulin and glucose concentrations were measured. Horses were grouped by outcome (survival, hyperinsulinemia, and hyperglycemia) and compared with P < .05 considered significant. Fifty-eight horses were included in the study and 36 (62%) survived. At admission, 21 horses (36%) were hyperinsulinemic and 44 horses (88%) were hyperglycemic, with survivors having significantly higher serum insulin and a significantly lower serum glucose concentration. Horses diagnosed with hyperinsulinemia at any time during hospitalization were 4 times more likely to survive whereas horses that were hyperglycemic at any time during hospitalization were 5 times less likely to survive. Serum glucose concentration and presence of hyperglycemia both were associated with severity of disease. Insulin/glucose ratio, ref...Continue Reading

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Citations

Sep 13, 2019·Journal of Veterinary Internal Medicine·Allison J StewartTaylor J Towns
Feb 27, 2020·Journal of Veterinary Internal Medicine·Janice E KritchevskyFrancois-Rene Bertin
Mar 18, 2020·The Veterinary Record·Alexandra CunneenFrancois R Bertin
Apr 4, 2021·Animals : an Open Access Journal From MDPI·Gemma R HicksFrançois-René Bertin

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