PMID: 8591701Aug 1, 1995Paper

Insulin edema in diabetes mellitus associated with the 3243 mitochondrial tRNA(Leu(UUR)) mutation; case reports

Diabetes Research and Clinical Practice
Y SuzukiT Asahina

Abstract

We encountered a patient with diabetes mellitus due to the 3243 mitochondrial tRNA mutation(DM-Mt3243), who developed insulin edema and hepatic dysfunction after starting insulin. Such a rare phenomenon was unlikely to be a fortuitous coincidence in mitochondrial diabetes, as none in 197 non-mutant NIDDM patients had same episode. Moreover, similar leg edema was noticed in another DM-Mt3243 patient, and other two DM-Mt3243 patients had leg edema which responded to coenzyme Q10. These observations suggest further a role of mitochondrial function on leg edema. The mechanism of his insulin edema may involve vasomotor changes induced by the rapidly glycemic control, because our case of insulin edema had a prominent increase of strong succinate dehydrogenase reactive vessels. Alternatively, myocardial dysfunction might have produced leg edema and hepatic dysfunction, because he had subclinical myocardial dysfunction, judged by imaging with beta-methyl-p-(123I)-iodophenyl-pentadecanoic acid. The third explanation is that a rapid improvement of glycemic control might have induced hepatic reoxygenation and the production of reactive oxygen species in the liver that contributed to cell damage. Thus, although we cannot draw definite conc...Continue Reading

References

Jan 1, 1966·Transactions of the Royal Society of Tropical Medicine and Hygiene·A G Shaper
May 1, 1995·Diabetes Research and Clinical Practice·Y SuzukiK Matsuoka
Jan 1, 1995·Muscle & Nerve. Supplement·T KadowakiY Yazaki

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Citations

Sep 16, 2006·Journal of Paediatrics and Child Health·Dimitrios MamoulakisMaria Kalmanti
May 10, 2000·Journal of Endocrinological Investigation·B HirshbergM Shalit
May 29, 2013·European Journal of Pediatrics·Avinash AravamudhanSenthil Senniappan
Feb 26, 2008·Diabetic Medicine : a Journal of the British Diabetic Association·R MurphyA T Hattersley
Apr 19, 2003·European Journal of Gastroenterology & Hepatology·Takahiro ZendaKunimasa Yagi
Mar 18, 2006·Muscle & Nerve·Maria Grazia D'Angelo, Nereo Bresolin
Mar 15, 2005·Journal of Endocrinological Investigation·G KalambokisE V Tsianos
Sep 29, 2011·The Journal of Dermatology·Akiko SugiyamaMasutaka Furue

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