Insulin effect on adipose tissue (AT) adiponectin expression is regulated by the insulin resistance status of the patients

Clinical Endocrinology
J J Hernandez-MoranteM Garaulet

Abstract

The objective of the present study was to determine a possible depot-specific effect of insulin-stimulation on adiponectin gene expression in adipose tissue (AT) explants from subcutaneous and visceral AT. A secondary aim was to analyse the associations of adiponectin plasma levels, as well as control and insulin-stimulated gene expression levels with different features of the metabolic syndrome. Visceral and subcutaneous AT biopsies were obtained from 20 subjects (10 men and 10 women) with morbid obesity. Metabolic syndrome and other clinical features were studied. Adiponectin expression from isolated adipocytes was measured both in control and after insulin-stimulation conditions by quantitative PCR. Subcutaneous adipocytes expressed significantly higher amounts of adiponectin mRNA than visceral tissue (P = 0.027). Insulin increased adiponectin expression specifically in the omental tissue (P = 0.011). In these patients, waist : hip ratio was directly correlated with adiponectin expression in the visceral depot (r = 0.660; P = 0.014), while fasting glucose levels were inversely associated with adiponectin mRNA in the subcutaneous tissue (r =-0.604; P = 0.022). Adiponectin expression after addition of insulin was positively co...Continue Reading

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Citations

Jul 11, 2009·Journal of Physiology and Biochemistry·F I MilagroJ A Martínez
May 29, 2009·Current Opinion in Clinical Nutrition and Metabolic Care·Rachel P Wildman
Nov 6, 2009·Endocrinology·P Gómez-AbellánM Garaulet
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Feb 12, 2017·The Journal of Clinical Endocrinology and Metabolism·Andrea Di NisioCarlo Foresta
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Jun 21, 2018·PloS One·James ReneauSrividya Kidambi

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