Insulin enhancement of in vitro wound healing in fetal rat parietal bones

Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons
H YanoT Amagasa

Abstract

This study evaluated the effect of insulin on fracture in fetal rat intramembranous bone using an organ culture system in which bone mineralizes in vitro. Twenty-day-old fetal rat parietal bones were fractured parallel to the frontal plane and cultured in a serum-free medium with or without insulin for 4 to 12 days. They were then processed for light microscopy. In the specimens not treated with insulin, bony bridges were observed in less than 10% on day 4 and 8, and only 45% on day 12. In bones treated with insulin at 10(-6) mol/L, bony bridges were observed in 73% on day 4 and 100% on day 8 and 12. No callus or cartilage formation was observed during the wound repair process, indicating that intramembranous ossification occurred. These findings suggest that insulin has a direct effect on bone cells, which enhances the healing of fractures in intramembranous bone.

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Citations

Nov 24, 2004·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·T MajimaK Nakao
May 9, 2014·Burns : Journal of the International Society for Burn Injuries·Michael Hrynyk, Ronald J Neufeld
Apr 17, 2008·Journal of Diabetes and Its Complications·Inan AnaforogluMelek Eda Ertorer
Jul 19, 2005·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Israel DudkiewiczMoshe Salai

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