Insulin Facilitates the Recovery of Myocardial Contractility and Conduction during Cardiac Compression in Rabbits with Bupivacaine-Induced Cardiovascular Collapse.

Anesthesiology Research and Practice
Solmon YangKook-Hyun Lee

Abstract

Bupivacaine inhibits cardiac conduction and contractility. Insulin enhances cardiac repolarization and myocardial contractility. We hypothesizes that insulin therapy would be effective in resuscitating bupivacaine-induced cardiac toxicity in rabbits. Twelve rabbits were tracheally intubated and midline sternotomy was performed under general anesthesia. Cardiovascular collapse (CVC) was induced by an IV bolus injection of bupivacaine 10 mg/kg. The rabbits were treated with either saline (control) or insulin injection, administered as a 2 U/kg bolus. Internal cardiac massage was performed until the return of spontaneous circulation (ROSC) and the time to the return of sinus rhythm (ROSR) was also noted in both groups. Arterial blood pressure, and electrocardiography were continuously monitored for 30 min and plasma bupivacaine concentrations at every 5 min. The ROSC, ROSR and normalization of QRS duration were attained faster in the insulin-treated group than in the control group. At the ROSC, there was a significant difference in bupivacaine concentration between two groups. Insulin facilitates the return of myocardial contractility and conduction from bupivacaine-induced CVC in rabbits. However, recovery of cardiac conduction i...Continue Reading

References

Dec 1, 1992·Pflügers Archiv : European journal of physiology·K Zierler, F S Wu
Jan 1, 1991·Anesthesia and Analgesia·P LacombeC Hollmann
Jul 1, 1986·British Journal of Anaesthesia·S Reiz, S Nath
Sep 1, 1987·Journal of Cardiovascular Pharmacology·M P GuptaN S Dhalla
Jan 1, 1984·Anesthesiology·C S Jones
Jan 1, 1984·Anesthesiology·D M KotelkoM A Rosen
Oct 26, 2000·Anesthesia and Analgesia·H S ChoK H Lee

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.

Cardiac Conduction System

The cardiac conduction system is a specialized tract of myocardial cells responsible for maintaining normal cardiac rhythm. Discover the latest research on the cardiac conduction system here.

Related Papers

Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie
Mi-Hyun KimByeong-Chul Kang
Korean journal of anesthesiology
Yun Suk Choi, Kook-Hyun Lee
Anesthesia and Analgesia
Marcio G KiuchiR T Sudo
Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie
Jin-Tae KimKook-Hyun Lee
© 2021 Meta ULC. All rights reserved