Insulin growth factor-1 protects against excitotoxicity in the rat striatum

Neuroreport
Carole EscartinEmmanuel Brouillet

Abstract

Recent findings demonstrated the neuroprotective effects of insulin-like growth factor 1 (IGF-1) in a cultured cell model of Huntington's disease. In the present study, we examined the potential neuroprotective effect of IGF-1 in vivo, in a rat model of Huntington's disease using the NMDA receptor agonist quinolinate. Continuous intracerebroventricular infusion of recombinant IGF-1 (0.25 microg/h for 2 days) in the rat brain, produced a significant 8-fold increase in striatal levels of the growth factor. Histological evaluation after intrastriatal injection of quinolinate showed that IGF-1 treatment significantly attenuated striatal degeneration. These results further support the therapeutic interest of IGF-1 in Huntington's disease.

References

Jan 1, 1992·Trends in Neurosciences·R E Coggeshall
Mar 1, 1994·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·C Z Zhu, R N Auer
Aug 27, 1993·Annals of the New York Academy of Sciences·V R SaraP A Ståhlbom
Jul 1, 1993·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·J GuanP Gluckman
Feb 21, 1997·Cell·T F FrankeL C Cantley
Mar 14, 1998·Proceedings of the National Academy of Sciences of the United States of America·A M FernandezI Torres-Aleman
Aug 5, 1999·Cellular Signalling·F H Nystrom, M J Quon
Dec 28, 1999·Cell·T F Vogt, D Duboule

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Citations

Sep 18, 2007·Neuroscience Letters·Carole EscartinEmmanuel Brouillet
Dec 17, 2008·Annals of the New York Academy of Sciences·Mark P Mattson
Jun 1, 2007·Amyotrophic Lateral Sclerosis : Official Publication of the World Federation of Neurology Research Group on Motor Neuron Diseases·Andrew P Smith, Nancy M Lee

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