PMID: 7021484Jan 1, 1981Paper

Insulin immunohistochemistry of rodent CNS: apparent species differences but good correlation with radioimmunological data

Histochemistry
A DornH Rummelfänger

Abstract

Using an indirect immunofluorescence technique the distribution of insulin was mapped in brains of Wistar strain rats and mice. Insulin immunoreactivity was found to be widely distributed throughout mouse CNS, whereas in rat brain a restriction of immunoreactive material to cerebral blood vessels and ependymal cells and/or tanycytes of the brain ventricles was observed. In radioimmunological studies the amount of insulin (IRI) was estimated for different brain areas (cerebral cortex, brain stem, cerebellum, hippocampus, thalamus and hypothalamus). In the case of Wistar rats very low levels of IRI were found. On the contrary, the same regions in mouse brain contained considerably greater amounts of IRI. The comparison between histochemical and biochemical data revealed a good correlation. It is concluded that part of the insulin measured by radioimmunoassay is associated with neuronal structures.

References

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Citations

Mar 1, 1983·Cellular and Molecular Neurobiology·J A Weyhenmeyer, R E Fellows
Jan 1, 1986·Neuroscience and Biobehavioral Reviews·S P Grossman
Jan 1, 1993·Neurochemistry International·M WozniakM K Raizada
Jan 1, 1982·Acta histochemica·A DornM Ziegler
Jan 1, 1982·Acta histochemica·A DornM Ziegler
Jan 1, 1991·Neuroscience and Biobehavioral Reviews·C R Plata-Salamán
Jan 1, 1991·Trends in Endocrinology and Metabolism : TEM·K A Heidenreich
Sep 1, 1983·The Anatomical Record·A DornS Ansorge
May 1, 1984·Journal of Neurochemistry·N R ZahniserJ V Vinych
Jan 1, 1992·Journal of Receptor Research·M WatanabeM Shimada
Mar 4, 2014·Progress in Neurobiology·Fares BassilWassilios G Meissner
Aug 1, 1998·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·M WatanabeM Shimada

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