Insulin in the arcuate nucleus of the hypothalamus reduces fat consumption in rats

Brain Research
G Van DijkJan H Strubbe

Abstract

Data are accumulating that insulin acting in the central nervous system is a physiological regulator of food intake and body weight, presumably via its effect in the hypothalamus. The present study investigated whether infusion of a small dose of insulin into two major hypothalamic insulin-binding areas also has an effect on diet selection and behavior. At the beginning of the dark period, rats received local bilateral infusions of 4 microU of insulin or vehicle during 34 min into the arcuate (ARC) or paraventricular (PVN) nucleus of the hypothalamus. Consumption of carbohydrate (C)-, protein (P)-, and fat (F)-enriched food and time spent on certain behaviors (drinking, resting, grooming, rearing, exploring/sniffing) were assessed during the first nocturnal hour. In addition, 21-h diet selection was assessed. The percentage contribution of macronutrients (C/P/F) to total energy content of the C-, P-, and F-enriched diets was 71.9/17.2/10.9, 45.8/43.4/10.8, and 47.1/17.5/35.4, respectively. During the first hour, infusion of insulin into the PVN increased grooming behavior compared to infusion of the vehicle. Although infusion of insulin had no effect on diet selection during the first hour, insulin infused in the ARC caused a r...Continue Reading

Citations

Jan 30, 2004·American Journal of Physiology. Endocrinology and Metabolism·Dianne P FiglewiczJohn F Neumaier
Apr 11, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·M LiuP Tso
Aug 31, 2012·American Journal of Physiology. Endocrinology and Metabolism·Adam P ChambersRandy J Seeley
Oct 30, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Lene JessenStephan D Bouman
Dec 18, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Deborah J CleggBarry E Levin
Jan 31, 2021·CNS Drugs·Manfred Hallschmid

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