Insulin Inclusion into a Tragacanth Hydrogel: An Oral Delivery System for Insulin

Materials
Mokhamad Nur, T Vasiljevic

Abstract

Nanoparticles or microparticles created by physical complexation between two polyelectrolytes may have a prospective use as an excipient for oral insulin administration. Natural polymers such as tragacanth, alginate, dextran, pullulan, hyaluronic acid, gelatin and chitosan can be potential candidates for this purpose. In this research, insulin particles were prepared by the inclusion of insulin into a tragacanth hydrogel. The effect of the pH and concentration relationship involving polyelectrolytes offering individual particle size and zeta potential was assessed by zetasizer and scanning electron microscopy (SEM). Insulin-tragacanth interactions at varying pH (3.7, 4.3, 4.6, or 6), and concentration (0.1%, 0.5%, or 1% w/w) were evaluated by differential scanning calorimetry (DSC) and ATR Fourier transform infrared (ATR-FTIR) analysis. Individual and smaller particles, approximately 800 nm, were acquired at pH 4.6 with 0.5% of tragacanth. The acid gelation test indicated that insulin could be entrapped in the physical hydrogel of tragacanth. DSC thermograms of insulin-tragacanth showed shifts on the same unloaded tragacanth peaks and suggested polyelectrolyte-protein interactions at a pH close to 4.3-4.6. FTIR spectra of traga...Continue Reading

References

Jun 6, 2000·Advanced Drug Delivery Reviews·S Wee, W R Gombotz
Aug 4, 2001·Pharmaceutical Development and Technology·A MitrevejV Kositchaiyong
Jun 18, 2002·Artificial Cells, Blood Substitutes, and Immobilization Biotechnology·Seçil Onal, Figen Zihnioğlu
Sep 3, 2002·International Journal of Pharmaceutics·Kang Wang, Zhimin He
Mar 5, 2003·Journal of Biomaterials Applications·N K Kavitha Raj, Chandra P Sharma
Mar 26, 2003·Biotechnology and Bioengineering·Noriho Kamiya, Alexander M Klibanov
Apr 4, 2003·International Journal of Pharmaceutics·Waree TiyaboonchaiC Russell Middaugh
Apr 16, 2003·Journal of Controlled Release : Official Journal of the Controlled Release Society·Sinjan De, Dennis Robinson
Jan 20, 2004·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·J BergerR Gurny
Feb 22, 2005·Biomaterials·Rhongsheng ZhangJohn Hubble
Apr 28, 2005·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·António J RibeiroFrancisco Veiga
Sep 20, 2005·Carbohydrate Research·Tanja MimmoCarlo Gessa
Oct 4, 2005·Advanced Drug Delivery Reviews·John D Smart
Jan 31, 2006·International Journal of Pharmaceutics·Catarina M SilvaFrancisco Veiga
Jun 17, 2006·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Nicholas A Peppas, Nikhil J Kavimandan
Nov 15, 2006·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·B SarmentoM van de Weert
Aug 10, 2007·Acta Biochimica Et Biophysica Sinica·Jilie Kong, Shaoning Yu
Mar 15, 2008·Nanomedicine : Nanotechnology, Biology, and Medicine·Akbar BayatMorteza Rafiee-Tehrani
Sep 27, 2008·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yu-Hsin LinHsing-Wen Sung
May 19, 2009·Nanomedicine : Nanotechnology, Biology, and Medicine·Mohammad Reza AvadiMorteza Rafiee-Tehrani
Oct 15, 2009·International Journal of Pharmaceutics·C E Mora-HuertasA Elaissari
Feb 24, 2012·Colloids and Surfaces. B, Biointerfaces·Zhi Min WuYun Chen
Apr 24, 2012·Drug Discovery Today·T A Sonia, Chandra P Sharma
Nov 14, 2012·International Journal of Biological Macromolecules·Mohammad NejatianMohammad Amin Mohammadifar
Apr 10, 2013·International Journal of Biological Macromolecules·Djamel TahtatFatima Laraba-Djebari
Apr 17, 2014·Journal of Biomedical Nanotechnology·T A Sonia, Chandra P Sharma
May 13, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Hui-Peng LimEng-Seng Chan
May 20, 2015·International Journal of Biological Macromolecules·Mina FarziMohammad Amin Mohammadifar
Mar 10, 2016·International Journal of Biological Macromolecules·Khadijeh Hemmati, Mousa Ghaemy
Sep 11, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Lei LiXiangdong Kong
May 30, 2017·International Journal of Biological Macromolecules·Mokhamad Nur, Todor Vasiljevic

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Citations

Apr 25, 2020·Nanomaterials·Rosita PrimaveraAvnesh S Thakor

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Methods Mentioned

BETA
scanning electron microscopy

Software Mentioned

Shimadzu IR solution

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