PMID: 7018642Aug 3, 1981Paper

Insulin-induced elevation of hypothalamic norepinephrine turnover persists after glucorestoration unless feeding occurs

Brain Research
S I Bellin, S Ritter

Abstract

We employed a delayed feeding paradigm to assess regional brain catecholamine changes associated with insulin-elicited glucoprivic feeding. This paradigm makes use of the recent discovery that glucoprivic challenges significantly enhance food intake even when food is withheld until other signs of glucoprivation have abated. Using this paradigm we attempted to temporally dissociate the neurochemical events associated with the ingestive response from other potentially confounding consequences of insulin or glucoprivation. We found a high degree of congruence between elevated hypothalamic norepinephrine (NE) turnover (estimated by the change in transmitter concentration after synthesis inhibition) and the persistence of hunger, both during and after apparent glucoprivation. In the absence of food, hypothalamic NE turnover was enhanced during insulin-induced glucoprivation and this increase persisted into the postglucoprivic period. A brief feeding bout, either during glucoprivation or postglucoprivically, rapidly normalized NE turnover rates. Moreover, brief access (30 min) to a limited quantity of food (2.5 g) during glucoprivation abolished both the elevated turnover and the feeding response otherwise observed postglucoprivicall...Continue Reading

References

Oct 17, 1975·Brain Research·J F LordenD L Margules
Sep 1, 1975·Pharmacology, Biochemistry, and Behavior·J Van Der Gugten, J L Slangen
Jul 1, 1973·Electroencephalography and Clinical Neurophysiology·B S Meldrum, R W Horton
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Feb 1, 1966·Journal of Comparative and Physiological Psychology·M H Smith

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Citations

Jan 1, 1986·Physiology & Behavior·C R Plata-SalamánN Shimizu
Mar 1, 1986·Pharmacology, Biochemistry, and Behavior·N KruissinkJ L Slangen
Jan 1, 1986·Neuroscience and Biobehavioral Reviews·S P Grossman
Jun 1, 1985·Brain Research Bulletin·N E RowlandJ Carlton
Mar 5, 1990·Brain Research·H Shimizu, G A Bray
Aug 5, 2006·Physiology & Behavior·Sue RitterAi-Jun Li
May 6, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Thu T DinhSue Ritter
Jan 2, 2014·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Ai-Jun LiSue Ritter
Sep 27, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Martin G de VriesJ Lee Beverly

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