Insulin-induced hypoglycemia suppresses plasma parathyroid hormone levels in patients with adrenal insufficiency

Metabolism: Clinical and Experimental
Abdulwahab M SulimanT Joseph McKenna

Abstract

Hypoglycemia has been reported to cause suppression of parathyroid hormone (PTH) levels in serum in normal subjects. It is possible that increasing cortisol levels in response to hypoglycemia was responsible. To examine this possibility the acute PTH response to insulin administration and resulting hypoglycemia was examined in patients with adrenal insufficiency. The possible acute impact of insulin-induced hypoglycemia on bone formation and bone resorption in the absence of an endogenous cortisol response was also examined. A prospective open study was undertaken to examine the acute effects of insulin and resulting hypoglycemia on PTH levels, on bone formation as indicated by serum levels of aminoterminal propeptide of type 1 procollagen (PINP), and on bone resorption as indicated by serum levels of beta carboxy terminal telopeptide of type 1 collagen (beta-CTx). Seven patients with adrenal insufficiency participated. These patients were studied on 3 occasions under different conditions: (1) when insulin was administered to induce hypoglycemia while the patients received their routine glucocorticoid replacement; (2) when the patients received their routine glucocorticoid replacement, but were not rendered hypoglycemic; and (3...Continue Reading

References

Dec 1, 1984·Experimental and Clinical Endocrinology·S LjunghallL Wide
Dec 1, 1984·Experimental and Clinical Endocrinology·S LjunhgallL Wide
May 20, 1999·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·E D'ErasmoM Acca

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