PMID: 11331217May 2, 2001Paper

Insulin, leptin, IGF-I and insulin-dependent protein concentrations after insulin-sensitizing therapy in obese women with polycystic ovary syndrome

European Journal of Endocrinology
I KowalskaI Kinalska

Abstract

To determine the clinical, hormonal and biochemical effect of 4-5 months of insulin-sensitizing therapy (hypocaloric diet+metformin) in obese patients with polycystic ovary syndrome (PCOS). Prospective study. Twenty-three obese patients with PCOS, 19 obese patients without menstrual disturbances and 11 healthy control women were recruited from the Department of Endocrinology and Endocrine Gynecology, Medical Academy, Bialystok, Poland. Obese patients received 500 mg metformin together with hypocaloric diet three times daily for 4-5 months, after baseline study. The clinical parameters, menstrual pattern and serum concentrations of insulin, leptin, IGF-I, insulin-dependent proteins (sex hormone-binding protein (SHBG), insulin-like growth factor-binding protein-1 (IGFBP-1)), gonadotropins and sex steroids were determined before and after treatment. In the baseline study, obese patients with PCOS had significantly higher insulin, testosterone and LH concentrations in comparison with the other groups. The serum leptin, IGF-I, IGFBP-1 and SHBG were not different between the two groups of obese patients, but there was a significant difference in comparison with the control group. After metformin therapy a significant reduction in BMI...Continue Reading

Citations

Jul 18, 2003·Current Diabetes Reports·Charles J GlueckPing Wang
Jan 9, 2004·Fertility and Sterility·Fábio Vasconcellos Comim, Poli Mara Spritzer
Mar 12, 2004·Metabolism: Clinical and Experimental·Marzieh SalehiLeonid Poretsky
May 14, 2003·Journal of Pediatric and Adolescent Gynecology·Heather Dean
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Apr 17, 2010·Reproduction : the Official Journal of the Society for the Study of Fertility·Christopher J Brewer, Adam H Balen
Jul 25, 2014·The Journal of Endocrinology·Sharon H Chou, Christos Mantzoros
Aug 2, 2002·Expert Opinion on Pharmacotherapy·Charles J GlueckPing Wang
Nov 20, 2002·Expert Opinion on Pharmacotherapy·Charles J GlueckPing Wang
Jul 27, 2014·Orvosi hetilap·Sándor Gődény, Orsolya Csenteri
Nov 19, 2014·Orvosi hetilap·Ildikó Kohlné Papp
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Aug 18, 2004·Annals of Saudi Medicine·Tayfun AlperArif Kokcu
Feb 26, 2009·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Massimiliano CazzanigaAndrea Decensi

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