Insulin-like Growth Factor 1 Differentially Affects Lithium Sensitivity of Lymphoblastoid Cell Lines from Lithium Responder and Non-responder Bipolar Disorder Patients

Journal of Molecular Neuroscience : MN
Elena MilanesiDavid Gurwitz

Abstract

Bipolar disorder (BD) is a chronic psychiatric illness with an unknown etiology. Lithium is considered the cornerstone in the management of BD, though about 50-60 % of patients do not respond sufficiently to chronic treatment. Insulin-like growth factor 1 (IGF1) has been identified as a candidate gene for BD susceptibility, and its low expression has been suggested as a putative biomarker for lithium unresponsiveness. In this study, we examined the in vitro effects of insulin-like growth factor 1 (IGF-1) on lithium sensitivity in lymphoblastoid cell lines (LCLs) from lithium responder (R) and non-responder (NR) bipolar patients. Moreover, we evaluated levels of microRNA let-7c, a small RNA predicted to target IGF1. We found that exogenous IGF-1 added to serum-free media increased lithium sensitivity selectively in LCLs from NR BD patients. However, no significant differences were observed when comparing let-7c expression in LCLs from R vs. NR BD patients. Our data support a key role for IGF-1 in lithium resistance/response in the treatment of bipolar disorder.

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Citations

Apr 17, 2016·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Alessio SquassinaMaria Del Zompo
Sep 13, 2016·Cytokine & Growth Factor Reviews·Alma Y Galvez-ContrerasOscar Gonzalez-Perez
Sep 17, 2016·Drug Development Research·Claudia PisanuAlessio Squassina
Nov 2, 2016·Psychiatry and Clinical Neurosciences·Ekaterina SigitovaJiří Raboch
Jan 17, 2017·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Elena MilanesiLuisella Bocchio-Chiavetto
Jan 18, 2017·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Pierre A GeoffroyCynthia Marie-Claire
Nov 23, 2017·Frontiers in Molecular Neuroscience·Keren OvedNoam Shomron
Aug 4, 2018·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Heba M Eltahir
Jun 16, 2017·Journal of Molecular Neuroscience : MN·Eleni Merkouri PapadimaAlessio Squassina
Sep 1, 2017·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Elena MilanesiDavid Gurwitz
Aug 24, 2017·Drug Development Research·David Gurwitz
May 24, 2018·Molecular Diagnosis & Therapy·Claudia PisanuAlessio Squassina
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Jun 10, 2020·Journal of Psychiatric Research·Gabriel R FriesConsuelo Walss-Bass
Oct 20, 2018·Neuropsychobiology·Ewa Ferensztajn-RochowiakJanusz K Rybakowski

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