Insulin-like growth factor-1 (IGF-1) enhances recovery from HgCl2-induced acute renal failure: the effects on renal IGF-1, IGF-1 receptor, and IGF-binding protein-1 mRNA.

Journal of the American Society of Nephrology : JASN
M FriedlaenderItamar Raz

Abstract

Several growth factors have been found to play an important role in the recovery from acute renal failure (ARF). The effect of the continuous subcutaneous infusion of human recombinant insulin-like growth factor (IGF)-1 (125 micrograms daily by osmotic minipumps) in a rat model of mercuric chloride (HgCl2)-induced ARF was examined. HgCl2 (4 mg/kg) induced ARF with a mortality that was unaffected by IGF-1. However, IGF-1 significantly enhanced functional and histologic recovery in the survivors, as measured by serum creatinine and creatinine clearance and by histologic scoring. Solution hybridization RNAase protection assays showed that renal IGF-1 mRNA, IGF-1 receptor (IGF-1R) mRNA, and IGF-binding protein-1 (IGFBP-1) mRNA were unaffected by exogenous IGF-1, but this treatment significantly increased renal IGF-1 in ARF rats compared with normal rats and ARF rats not receiving IGF-1. After ARF renal mRNA for IGF-1 was decreased, IGF-1R was unchanged and IGFBP-1 was increased. Similar changes occurred in IGF-1-infused ARF rats. Thus, (1) IGF-1 enhances recovery from nephrotoxic ARF both functionally and histologically; (2) in nephrotoxic ARF, there is (a) a reduction in IGF-1 mRNA expression that is not prevented by IGF-1 infusio...Continue Reading

Citations

Aug 5, 1998·Current Opinion in Nephrology and Hypertension·M R Hammerman
Aug 26, 1999·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·M R Hammerman
Jan 29, 2000·Kidney International·M R Hammerman
May 29, 2002·Life Sciences·I Ibáñez de CáceresM A Villanúa
Jun 19, 2021·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Dieter HaffnerMaren Leifheit-Nestler
May 11, 1999·The Journal of Laboratory and Clinical Medicine·F C FervenzaR Rabkin
Sep 15, 2000·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·G L Matejka, B A Bengtsson
Nov 2, 2006·Current Opinion in Critical Care·Sean M Bagshaw
Oct 19, 2007·Journal of the American Society of Nephrology : JASN·Barbara ImbertiGiuseppe Remuzzi
Feb 1, 2008·Clinical Journal of the American Society of Nephrology : CJASN·Claudio RoncoAndrew A House
May 9, 1998·Renal Failure·M M FriedlaenderR Rabkin

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