PMID: 9658334Jul 11, 1998Paper

Insulin-like growth factor-1 is a radial cell-associated neurotrophin that promotes neuronal recruitment from the adult songbird edpendyma/subependyma

Journal of Neurobiology
J JiangS A Goldman

Abstract

In the adult songbird forebrain, neurons continue to be produced from precursor cells in the forebrain ependymal/subependymal zone (SZ), from which they migrate upon radial guide fibers. The new neurons and their radial cell partners may coderive from a common SZ progenitor, which may be the radial cell itself. On this basis, we asked whether radial cells might provide trophic support for the migration or survival of newly generated neurons. We focused upon the insulin-like growth factors (IGFs) IGF-1 and IGF-2, which have previously been shown to support the survival and differentiation of neural progenitor cells. We found that IGF-1 immunoreactivity was expressed heavily by adult zebra finch radial cells and their fibers, with little expression otherwise. IGF-2, in contrast, was expressed by parenchymal astrocytes and exhibited little radial cell expression. Despite their distinct distributions, IGF-1 and IGF-2 exerted similar trophic effects on finch SZ cells in vitro; both greatly increased the number of neurons migrating from explants of the adult finch SZ, relative to explants raised in low-insulin, IGF-1-deficient media. However, neither factor extended neuronal survival. These results suggest that in neurogenic regions ...Continue Reading

References

Jan 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·J E Bottenstein, G H Sato
Aug 21, 1992·Brain Research. Developmental Brain Research·S A Goldman, M Nedergaard
Sep 1, 1992·Journal of Neurobiology·E A Brenowitz, A P Arnold
Mar 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·J DragoP F Bartlett
May 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·B A Schlinger, A P Arnold
Sep 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·M K LeeA Frankfurter
Sep 1, 1989·Brain Research. Developmental Brain Research·E J Nordeen, K W Nordeen
Jun 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·E DiCicco-Bloom, I B Black
Sep 22, 1988·Nature·A Alvarez-Buylla, F Nottebohm
Jan 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·F StylianopoulouA Efstratiadis
Feb 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·F A McMorrisR W Furlanetto
Apr 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·S A Goldman, F Nottebohm
Nov 21, 1995·Proceedings of the National Academy of Sciences of the United States of America·F SohrabjiC D Toran-Allerand
Jan 1, 1995·Annals of Internal Medicine·D LeRoithC T Roberts
Aug 1, 1993·Molecular Reproduction and Development·D R Clemmons
Jan 3, 1995·Proceedings of the National Academy of Sciences of the United States of America·B Kirschenbaum, S A Goldman
Aug 16, 1994·Proceedings of the National Academy of Sciences of the United States of America·S RasikaA Alvarez-Buylla
Mar 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·C Lois, A Alvarez-Buylla
Jun 11, 1996·Proceedings of the National Academy of Sciences of the United States of America·G G KuiperJ A Gustafsson

❮ Previous
Next ❯

Citations

Feb 19, 2000·Journal of Neuroscience Research·G J BrookerP F Bartlett
May 25, 2010·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Nazia KhurshidSoumya Iyengar
Mar 10, 2000·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·M HolzenbergerC Ayer-LeLièvre
Aug 18, 2004·Annals of the New York Academy of Sciences·Linda Wilbrecht, John R Kirn
Apr 19, 2007·Clinical and Experimental Pharmacology & Physiology·Helen E Grote, Anthony J Hannan
Apr 25, 2012·PloS One·Christopher K ThompsonEliot A Brenowitz
Jul 8, 1999·Proceedings of the National Academy of Sciences of the United States of America·F DittrichM Gahr
Jun 6, 2000·Trends in Neurosciences·A D Tramontin, E A Brenowitz
Oct 11, 2003·Molecular and Cellular Neurosciences·Maria A I AbergPeter S Eriksson
Oct 31, 2003·Trends in Neurosciences·Steve Goldman
Nov 24, 2004·The Journal of Comparative Neurology·Valerie Dewulf, Sarah W Bottjer

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.