Abstract
Radiotherapy for head-and-neck cancer consists of fractionated radiation treatments that cause significant damage to salivary glands leading to chronic salivary gland dysfunction with only limited prevention and treatment options currently available. This study examines the feasibility of IGF-1 in preserving salivary gland function following a fractionated radiation treatment regimen in a pre-clinical model. Mice were exposed to fractionated radiation, and salivary gland function and histological analyses of structure, apoptosis, and proliferation were evaluated. In this study, we report that treatment with fractionated doses of radiation results in a significant level of apoptotic cells in FVB mice after each fraction, which is significantly decreased in transgenic mice expressing a constitutively active mutant of Akt1 (myr-Akt1). Salivary gland function is significantly reduced in FVB mice exposed to fractionated radiation; however, myr-Akt1 transgenic mice maintain salivary function under the same treatment conditions. Injection into FVB mice of recombinant insulin-like growth factor-1 (IGF-1), which activates endogenous Akt, suppressed acute apoptosis and preserved salivary gland function after fractionated doses of radiati...Continue Reading
References
Nov 1, 1991·Special Care in Dentistry : Official Publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry·I H Valdez
Apr 1, 1985·The Journal of the American Dental Association·P C FoxB J Baum
Mar 30, 1995·International Journal of Radiation Oncology, Biology, Physics·J S CooperS Silverman
Aug 5, 1998·International Journal of Radiation Biology·G M PaardekooperA W Konings
Oct 19, 1999·International Journal of Radiation Oncology, Biology, Physics·A EisbruchJ A Ship
Jan 6, 2000·Oral Oncology·B S HensonJ A Ship
Jan 12, 2000·Archives of Disease in Childhood·D Hall
Sep 17, 2002·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·Reinhard E FriedrichChristine Lautenschläger
May 23, 2003·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·C SagowskiM Jaehne
Dec 14, 2004·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Barbara BusselsWalter Van den Bogaert
Jun 29, 2005·Annals of Biomedical Engineering·Taili T ThulaChristopher Batich
Sep 13, 2006·International Journal of Radiation Oncology, Biology, Physics·Pètra M BraamCornelis P J Raaijmakers
Sep 20, 2006·Molecular and Cellular Biology·Kirsten H LimesandSteven M Anderson
Dec 5, 2006·International Journal of Radiation Oncology, Biology, Physics·Yun LiAvraham Eisbruch
Mar 14, 2008·International Journal of Radiation Oncology, Biology, Physics·Carol-Anne Murdoch-KinchAvraham Eisbruch
Apr 29, 2008·Brazilian Dental Journal·George BoraksRenato Paulo Chopard
May 1, 2008·PloS One·Isabelle M A LombaertRobert P Coppes
Jan 17, 2009·International Journal of Radiation Oncology, Biology, Physics·Jennifer L AvilaKirsten H Limesand
Jan 27, 2009·Trends in Cell Biology·Paul R Clarke, Lindsey A Allan
Mar 3, 2009·PloS One·Kirsten H LimesandSteven M Anderson
Sep 29, 2009·Journal of Dental Research·O GrundmannK H Limesand
Citations
Nov 16, 2010·Journal of Dental Research·K VictoryK H Limesand
Aug 12, 2010·BMC Cancer·Oliver GrundmannKirsten H Limesand
Dec 14, 2012·PloS One·Katie L MartinKirsten H Limesand
Feb 26, 2016·International Journal of Radiation Oncology, Biology, Physics·Youssef H ZeidanDavud Sirjani
Feb 22, 2012·International Journal of Radiation Oncology, Biology, Physics·Bo HaiFei Liu
May 7, 2013·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Laura S SasportasDavud Sirjani
Dec 17, 2014·Journal of Prosthodontic Research·Phuu HanRoseann Mulligan
Sep 23, 2014·PloS One·Alejandro M ChiblyKirsten H Limesand
Oct 12, 2015·Archives of Oral Biology·Monique Dossena AcauanFernanda Gonçalves Salum
Jun 7, 2014·Scientific Reports·Maria Morgan-BathkeKirsten H Limesand
Jun 21, 2015·Journal of Dental Research·M Morgan-BathkeK H Limesand
Jul 26, 2013·Journal of Dental Research·M Morgan-BathkeK H Limesand
Jan 14, 2017·Oncotarget·Jeong-Seok ChoiJae-Yol Lim
Dec 1, 2019·Scientific Reports·Dany GaillardLinda A Barlow
Nov 20, 2014·PloS One·Grace HillKirsten H Limesand
Oct 27, 2015·Journal of Biomedical Optics·Monique Dossena AcauanFernanda Gonçalves Salum
Apr 22, 2018·Scientific Reports·Alejandro M ChiblyKirsten H Limesand
Mar 21, 2019·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Kristy E GilmanKirsten H Limesand
Oct 24, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Bo HaiFei Liu
Feb 2, 2021·Physiological Genomics·Lauren MeeksMegha Padi
Mar 24, 2021·Journal of Dental Research·J M ChoJ Y Lim