Insulin-like growth factor-1 receptor inhibitor, AMG-479, in cetuximab-refractory head and neck squamous cell carcinoma.

Head & Neck
Christine H ChungBarbara Murphy

Abstract

Recurrent head and neck squamous cell carcinoma (HNSCC) remains a difficult cancer to treat. Here, we describe a patient with HNSCC who had complete response to methotrexate (MTX) after progressing on multiple cytotoxic agents, cetuximab, and AMG-479 (monoclonal antibody against insulin-like growth factor-1 receptor [IGF-1R]). The clinical information was collected by a retrospective medical record review under an Institutional Review Board-approved protocol. From 4 tumors and 2 normal mucosal epithelia, global gene expression, and IGF-1R and dihydrofolate reductase (DHFR) protein levels were determined. Effective target inhibition in the tumor was confirmed by the decreased protein levels of total and phospho-IGF-1R after treatment with AMG-479. Decreased level of DHFR and conversion of a gene expression profile associated with cetuximab-resistance to cetuximab-sensitivity were also observed. This suggests that the combination of AMG-479 and MTX or cetuximab may be a promising therapeutic approach in refractory HNSCC.

References

Jun 13, 1998·Journal of the National Cancer Institute·J Rubin GrandisD J Tweardy
Mar 10, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·David B SolitFrank M Sirotnak
Sep 1, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Christine H ChungFred R Hirsch
Dec 15, 2006·The New England Journal of Medicine·Alan SandlerDavid H Johnson
Apr 20, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Bruce J GiantonioUNKNOWN Eastern Cooperative Oncology Group Study E3200
Jul 20, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Christopher J BarnesRakesh Kumar
Aug 21, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Wu ZhangHeinz-Josef Lenz
Sep 18, 2007·Journal of Molecular Biology·Jordan P VolpatoJoelle N Pelletier
Sep 12, 2008·The New England Journal of Medicine·Jan B VermorkenRicardo Hitt

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Citations

Aug 25, 2012·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·He WangVikram Deshpande
Jul 3, 2013·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Kirsten H LimesandAndrew Fribley
Oct 18, 2011·Expert Opinion on Drug Metabolism & Toxicology·Joshua G YorgasonFederico Kalinec
Apr 5, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Amanda PsyrriArlene A Forastiere
Mar 16, 2021·Frontiers in Oncology·Sandra Ortiz-CuaranPierre Saintigny

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