Insulin-like growth factor-1 reduces postischemic white matter injury in fetal sheep

Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
J GuanA J Gunn

Abstract

Insulin-like growth factor-1 (IGF-1) is known to be important for oligodendrocyte survival and myelination. In the current study, the authors examined the hypothesis that exogenous IGF-1 could reduce postischemic white matter injury. Bilateral brain injury was induced in near-term fetal sheep by 30 minutes of reversible carotid artery occlusion. Ninety minutes after ischemia, either vehicle (n = 8) or a single dose of 3 microg IGF-1 (n = 9) was infused intracerebroventricularly over 1 hour. White matter changes were assessed after 4 days recovery in the parasagittal intragyral white matter and underlying corona radiata. Proteolipid protein (PLP) mRNA staining was used to identify bioactive oligodendrocytes. Glial fibrillary acidic protein (GFAP) and isolectin B-4 immunoreactivity were used to label astrocytes and microglia, respectively. Myelin basic protein (MBP) density and the area of the intragyral white matter tracts were determined by image analysis. Insulin-like growth factor-1 treatment was associated with significantly reduced loss of oligodendrocytes in the intragyral white matter (P < 0.05), with improved MBP density (P < 0.05), reduced tissue swelling, and increased numbers of GFAP and isolectin B-4 positive cells c...Continue Reading

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Citations

Mar 1, 2012·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Charanjit KaurEng-Ang Ling
Feb 21, 2008·Neuromolecular Medicine·M Llorens-MartínJosé L Trejo
Mar 28, 2012·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Zoltan Ungvari, Anna Csiszar
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May 7, 2016·Journal of Neuropathology and Experimental Neurology·Jiyong ZhangBarbara S Stonestreet

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Methods Mentioned

BETA
PCR
in vitro transcription
acetylation
light microscopy

Software Mentioned

Sigmascan
SPSS

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