Insulin-like growth factor 2 mRNA-binding protein-3 as a marker for distinguishing between cutaneous squamous cell carcinoma and keratoacanthoma

International Journal of Oncology
Akiko KanzakiZenya Naito

Abstract

In the histopathological diagnosis of cutaneous tumors, the differential diagnosis of squamous cell carcinoma (SCC) with crateriform architecture and keratoacanthoma (KA) is often difficult so an accurate understanding of the biological features and the identification of reliable markers of SCC and KA are crucial issues. Insulin-like growth factor 2 mRNA-binding protein-3 (IGF2BP3, also known as IMP3) is thought of as a bona fide oncofetal protein, which is overexpressed and is involved in cell proliferation, migration, and invasion in several kinds of tumors. However, the role of IMP3 in cutaneous SCC and KA has not been well studied. Therefore, we focused on studying the biological functions of IMP3 in SCC and KA. In human skin SCC cell lines, HSC-1 and HSC-5, and the human keratinocyte cell line, HaCaT, IMP3 mRNA levels were significantly higher than that of normal human skin. The knockdown of IMP3 expression reduced the proliferation of HSC-1, and significantly reduced invasion by HSC-1 and HSC-5. In contrast, the knockdown of IMP3 did not significantly affect invasion by HaCaT cells. In immunohistochemical studies of SCC and KA tissues, the Ki-67 labeling index (LI) of the suprabasal cell layer was significantly higher in ...Continue Reading

References

Dec 1, 1979·Journal of Surgical Oncology·R A Schwartz
Aug 1, 1993·The American Journal of Dermatopathology·E HodakA B Ackerman
Aug 19, 2000·The American Journal of Dermatopathology·E Sánchez YusE de Eusebio
Mar 21, 2002·Histopathology·D C Brown, K C Gatter
Mar 20, 2003·British Journal of Cancer·T WangS G Reed
Jul 29, 2005·Reproduction : the Official Journal of the Society for the Study of Fertility·Niels A HammerFinn C Nielsen
Dec 15, 2007·Pathology, Research and Practice·Daniel RibeiroMariângela E A Marques
Jan 22, 2008·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Jennifer G PryorHaodong Xu
Mar 25, 2008·The American Journal of Dermatopathology·Steven KossardCarolyn Choy
Aug 25, 2009·Human Pathology·Rebecca L KingAdam Bagg
Sep 8, 2009·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Mark J MentrikoskiHaodong Xu
Oct 1, 2009·Journal of Cutaneous Pathology·Limin YuLinglei Ma
Nov 10, 2009·Endocrine Pathology·Alberto RighiRicardo V Lloyd
Apr 24, 2010·The American Journal of Dermatopathology·David D WeedonRichard Williamson
Jun 26, 2010·ANZ Journal of Surgery·David WeedonRichard Williamson
Sep 23, 2011·The American Journal of Dermatopathology·Noriyuki MisagoYutaka Narisawa
Nov 10, 2011·The Journal of Craniofacial Surgery·Hai-Gang LiXi-Ming Shen
May 31, 2012·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·T S ClauditzW Wilczak
Oct 1, 2011·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Chiao-Ying LinMark Yen-Ping Kuo
Feb 15, 2014·Clinical and Experimental Dermatology·N ScolaA Kreuter
Mar 22, 2014·Journal of Cancer Research and Clinical Oncology·Shuai HuGuoqiang Li

❮ Previous
Next ❯

Citations

Dec 2, 2017·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Tetsushi YamamotoAtsushi Taga
Nov 21, 2019·Molecular Medicine Reports·Hiroko OtakeNoriaki Nagai
Jul 13, 2021·Investigational New Drugs·Qiu-Ying DuDong-Sheng Pei
Dec 12, 2021·Journal of Cellular and Molecular Medicine·Yun XuPing Wang

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy
electrophoresis
ELISA

Software Mentioned

GraphPad Prism
GraphPad

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Related Papers

Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
Chiao-Ying LinMark Yen-Ping Kuo
© 2022 Meta ULC. All rights reserved