Insulin-like growth factor axis and risk of type 2 diabetes in women.

Diabetes
Swapnil N RajpathakHoward D Strickler

Abstract

IGF-I shares structural homology and in vitro metabolic activity with insulin. Laboratory models suggest that IGF-I and its binding proteins IGFBP-1 and IGFBP-2 have potentially beneficial effects on diabetes risk, whereas IGFBP-3 may have adverse effects. We therefore conducted a prospective nested case-control investigation of incident diabetes (n = 742 case subjects matched 1:1 to control subjects) and its associations with IGF-axis protein levels in the Nurses' Health Study, a cohort of middle-aged women. The median time to diabetes was 9 years. Statistical analyses were adjusted for multiple risk factors, including insulin and C-reactive protein. Diabetes risk was fivefold lower among women with baseline IGFBP-2 levels in the top versus bottom quintile (odds ratio [OR](q5-q1) = 0.17 [95% CI 0.08-0.35]; P trend < 0.0001) and was also negatively associated with IGFBP-1 levels (OR(q5-q1) = 0.37 [0.18-0.73]; P trend = 0.0009). IGFBP-3 was positively associated with diabetes (OR(q5-q1) = 2.05 [1.20-3.51]; P trend = 0.002). Diabetes was not associated with total IGF-I levels, but free IGF-I and diabetes had a significant association that varied (P interaction = 0.003) by insulin levels above the median (OR(q5-q1) = 0.48 [0.26-0....Continue Reading

References

Nov 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·J I JonesD R Clemmons
Feb 1, 1995·Endocrine Reviews·J I Jones, D R Clemmons
Jul 11, 1994·FEBS Letters·J FrystykH Orskov
Feb 1, 1997·Journal of Women's Health·G A ColditzS E Hankinson
Feb 7, 1998·Molecular and Cellular Endocrinology·M FedericiG Sesti
Sep 1, 1999·The Journal of Endocrinology·K RajkumarL J Murphy
Dec 10, 1999·Diabetes/metabolism Research and Reviews·J FrystykH Orskov
May 16, 2000·The Journal of Biological Chemistry·L J SchedlichR C Baxter
Mar 15, 2001·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·M WabitschW F Blum
Oct 12, 2002·American Journal of Physiology. Endocrinology and Metabolism·Josef V SilhaLiam J Murphy
Dec 6, 2002·Endocrine Reviews·Sue M Firth, Robert C Baxter
Jan 10, 2003·Diabetic Medicine : a Journal of the British Diabetic Association·R I G HoltP H Sönksen
Oct 28, 2003·Diabetes Care·Saul GenuthUNKNOWN Expert Committee on the Diagnosis and Classification of Diabetes Mellitus
Feb 28, 2004·Diabetes·Frank B HuJoAnn E Manson
Sep 1, 2004·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Jan Frystyk
Oct 29, 2004·The Journal of Clinical Endocrinology and Metabolism·Jian-Wen ChenJan Frystyk
Aug 17, 2005·The International Journal of Biochemistry & Cell Biology·Derek LeRoith, Oksana Gavrilova
Aug 12, 2006·Journal of Molecular Endocrinology·Klaus W FrommerMartin W Elmlinger
Feb 23, 2007·Nature Clinical Practice. Endocrinology & Metabolism·Derek LeRoith, Shoshana Yakar
Oct 2, 2007·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Swapnil N RajpathakRobert C Kaplan
Apr 10, 2008·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Marc J GunterHoward D Strickler
Oct 31, 2008·Endocrine Reviews·Marc-Andre CornierRobert H Eckel
Jan 16, 2009·Diabetes/metabolism Research and Reviews·Swapnil N RajpathakHoward D Strickler

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Citations

Jun 10, 2010·Journal of Immigrant and Minority Health·Swapnil N Rajpathak, Judith Wylie-Rosett
Dec 20, 2002·Blood Reviews·Derek L StirewaltJerald P Radich
Jan 1, 2014·Journal of Clinical Medicine·Padmalatha GurramWinston Campbell
Feb 21, 2014·ISRN Obesity·Moira S Lewitt
Jun 4, 2014·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Jeannette M BeasleyHoward D Strickler
Jun 25, 2014·Mitochondrion·Marco TomasettiLanfeng Dong
Dec 18, 2013·Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine·Neomi ShahRobert C Kaplan
Jan 23, 2013·Nature Reviews. Endocrinology·Norbert Stefan, Hans-Ulrich Häring
Jan 1, 2014·Journal of Clinical Medicine·Moira S LewittKerstin Hall
Jan 18, 2016·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Chino S Aneke-NashRobert C Kaplan
Jul 21, 2015·Annals of Pediatric Endocrinology & Metabolism·Min Sun Kim, Dae-Yeol Lee
May 20, 2015·Journal of the American Geriatrics Society·Chino S Aneke-NashRobert C Kaplan
May 28, 2014·International Journal of Cancer. Journal International Du Cancer·Konstantinos K TsilidisTimothy J Key
Nov 23, 2013·Expert Opinion on Therapeutic Targets·Rikke HjortebjergJan Frystyk
May 8, 2015·European Journal of Endocrinology·Aleksandr PeetUNKNOWN DIABIMMUNE Study Group
Jun 25, 2015·Journal of Cancer Epidemiology·Chelsea CatsburgThomas E Rohan
Apr 20, 2016·Scientific Reports·Elina M PetäjäHannele Yki-Järvinen
Apr 27, 2016·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Anna E MattlageSandra A Billinger
Jul 28, 2016·American Journal of Public Health·Graham A ColditzSusan E Hankinson
Jul 29, 2016·Obesity Surgery·Troels BrynskovTorben Lykke Sørensen
Feb 10, 2017·European Journal of Endocrinology·Rikke HjortebjergJan Frystyk
Oct 19, 2017·The Journal of Clinical Endocrinology and Metabolism·Chino S Aneke-NashRobert C Kaplan
Mar 23, 2018·Journal of Molecular Endocrinology·David R Clemmons
Nov 10, 2018·Diabetes·Tianyi HuangShelley S Tworoger
Mar 6, 2019·The American Journal of Clinical Nutrition·Dong HangMingyang Song
Mar 23, 2019·The British Journal of Nutrition·Minna E SimiläSatu Männistö
Jan 1, 2015·Expert Review of Endocrinology & Metabolism·Eugene J Fine, Richard David Feinman
Nov 8, 2016·The Journal of Clinical Endocrinology and Metabolism·Robert C KaplanAnne Newman
May 30, 2020·British Journal of Cancer·Xiaoshuang FengLorelei A Mucci

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Methods Mentioned

BETA
blood draw
ELISAs
transgenic

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