Insulin like growth factor-binding protein-1 as a marker for hyperinsulinemia in obese menopausal women

The Journal of Clinical Endocrinology and Metabolism
Harriette R MogulSteven R Gambert

Abstract

Hyperinsulinemia, a manifestation of insulin resistance, precursor of non-insulin dependent diabetes mellitus (NIDDM) and the hallmark of Syndrome X was assessed in 27 obese post-menopausal women. Insulin-like growth factor binding protein-1 (IGFBP-1), which had been shown previously to correlate inversely with insulin in animal and human studies, was evaluated as a diagnostic marker for abnormal glucose stimulated area under the curve (AUC) insulin (defined a priori as > or = 100 microU/ml). We performed analysis of variance and logistic regression to assess IGFBP-1 and other study covariates, including body mass index, blood pressure, lipids and measures of glucose and insulin in hyperinsulinemic vs. normal women and evaluated performance characteristics (sensitivity, specificity, positive and negative predictive values and accuracy rates). The mean IGFBP-1 was 6.1 ng/ml (95% confidence interval (CI) 3.1 to 8.9) for the hyper-insulinemic women compared to 33.5 ng/ml (CI 15.8 to 51.2) for normal women (P = .0027). At a cutoff point of 15ng/ml, which was selected to correspond to the lower 95% confidence limit for the normal study population, IGFBP-1 was abnormal in all 13 women with hyperinsulinemia and 4 women with normal ins...Continue Reading

Associated Clinical Trials

Citations

May 29, 2010·European Journal of Endocrinology·Moira S LewittKerstin Hall
Apr 8, 2009·Trends in Endocrinology and Metabolism : TEM·Stephen B Wheatcroft, Mark T Kearney
Aug 19, 2007·Biochemical and Biophysical Research Communications·Fan ZhangQimin Zhang

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