Insulin-like growth factor binding protein-1 in PCOS: a systematic review and meta-analysis

Human Reproduction Update
C J KellyH Lashen

Abstract

Despite extensive research, the pathogenesis of polycystic ovary syndrome (PCOS) remains unclear. Putatively, an elevated circulating concentration of insulin inhibits the production of insulin-like growth factor binding protein-1 (IGFBP-1), thus increasing the level of free IGF-I in serum and stimulating ovarian androgen production. Decreased IGFBP-1 has been reported in PCOS and in obesity; however, there are inconsistencies in the evidence. This systematic review and meta-analysis aimed to determine whether IGFBP-1 is decreased in PCOS when controlling for the influence of BMI. Articles published between 1988 and 2008 were searched using MEDLINE, PubMed, SCOPUS and Web of Knowledge. Unpublished literature, trials in progress, and recent reviews were also searched. Original articles were selected by two investigators. To be included, the study must have compared serum IGFBP-1 in two populations: either PCOS versus controls, or an overweight subgroup versus the normal weight subgroup in either population. From 617 identified articles, 12 were included in the meta-analysis. Data were abstracted by two reviewers independently and standardized for errors. The population difference is presented as the Weighted Mean Difference (95%...Continue Reading

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Citations

May 31, 2011·European Journal of Endocrinology·Jan IdkowiakWiebke Arlt
Jun 19, 2013·Indian Journal of Endocrinology and Metabolism·Sadishkumar KamalanathanThozhukat Sathyapalan
Jan 18, 2016·Journal of Adolescence·Siobhan B MitchellSean P Cumming
Nov 1, 2011·Fertility and Sterility·Dominique de ZieglerCharles Chapron
Jul 26, 2014·American Journal of Reproductive Immunology : AJRI·Yan YangRong Zhou
Jul 1, 2015·American Journal of Epidemiology·Fan MuStacey A Missmer
Dec 10, 2014·Best Practice & Research. Clinical Obstetrics & Gynaecology·Ioannis E MessinisKonstantinos Dafopoulos
Jul 1, 2012·Hormones : International Journal of Endocrinology and Metabolism·Georgios ValsamakisGeorge Mastorakos
Jul 23, 2021·International Journal of Adolescent Medicine and Health·Mehrukh ZehraviIrfat Ara

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