Insulin-like growth factor binding protein-3 predicts survival from acute childhood leukemia

Oncology
E PetridouDimitrios Trichopoulos

Abstract

To investigate whether the three principal components of the insulin-like growth factor (IGF) system, IGF-1, IGF-2 and IGF binding protein-3 (IGFBP-3), are associated with survival from childhood leukemia. 116 children, 0--14 years old, with newly diagnosed and bone-marrow-biopsy-confirmed acute childhood leukemia between 1993 and 1996 were followed up until death or March 31, 1998. IGF-1, IGF-2 and IGFBP-3 were measured at diagnosis and clinical data, including presence of hepatosplenomegaly and number of white blood cells, were available. After controlling for gender, age, indicators of clinical severity and the other measured components of the IGF system there was a statistically significant (p < 0.05) inverse association of IGFBP-3 with survival. An increment of one standard deviation in IGFBP-3 was associated with a 65% reduction of the death hazard among the children with leukemia. Neither IGF-1 nor IGF-2 was associated with survival in this data set. The presented empirical evidence in conjunction with the fact that IGFBP-3 modulates IGF-1 and IGF-2 bioavailability and is likely to have proapoptotic effects makes this compound a plausible independent predictor of survival from childhood leukemia.

Citations

Dec 21, 2011·Cancer Causes & Control : CCC·Mari-Anne RowlandsRichard M Martin
Oct 14, 2003·Cancer Genetics and Cytogenetics·Sílvia CasasSakari Knuutila
Aug 14, 2003·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Anders Juul
Aug 3, 2012·Genetic Testing and Molecular Biomarkers·Nadia Iskander ZakharyEmad Nabil Ebeid
May 2, 2012·Endocrine Reviews·Maria DalamagaChristos S Mantzoros
Jul 20, 2007·Pediatric Blood & Cancer·Kristin DawczynskiFelix Zintl
Mar 30, 2006·International Journal of Cancer. Journal International Du Cancer·Stefania BeniniKatia Scotlandi
Jul 10, 2009·International Journal of Cancer. Journal International Du Cancer·Geir Frode OyVivi Ann Flørenes
Dec 3, 2014·Metabolism: Clinical and Experimental·Fernando Miguel MendonçaCristina Abreu

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