Insulin-like growth factor binding protein 3 (IGFBP-3) potentiates TRAIL-induced apoptosis of human colorectal carcinoma cells through inhibition of NF-kappaB.

Cell Death and Differentiation
A C WilliamsT J Collard

Abstract

There is growing evidence that the insulin-like growth factor-binding protein 3 (IGFBP-3) can have IGF-independent effects on cell growth. However, despite the fact that IGFBP-3 has been reported to be both antiproliferative and proapoptotic, the molecular mechanisms underlying the action of IGFBP-3 have not been elucidated. We report that although addition of IGFBP-3 (either synthetic or secreted protein) had no effect on cell survival, IGFBP-3 (100 ng/ml) significantly enhanced TNF-related apoptosis-inducing ligand (TRAIL)-induced cell death in colonic carcinoma-derived cell lines (20-30% depending on cell line), whereas it had no effect on the survival of the TRAIL-resistant adenoma-derived cells. Both addition of IGFBP-3 protein to cell cultures or enforced expression of IGFBP-3 in the HT29 carcinoma cell line inhibited nuclear factor kappa B (NF-kappaB) activation in response to the induction of apoptosis by TRAIL. We propose that IGFBP-3 is a non-toxic NF-kappaB inhibitor, which could be used as an adjuvant in the treatment of colon cancer.

References

May 31, 1996·The Journal of Biological Chemistry·R M PittiA Ashkenazi
Jun 1, 1996·Current Biology : CB·S A MarstersA Ashkenazi
Aug 8, 1998·Trends in Cell Biology·D J Van AntwerpD R Green
Aug 28, 1998·Science·A Ashkenazi, V M Dixit
Jul 20, 1999·The Journal of Clinical Investigation·A AshkenaziR H Schwall
Dec 22, 1999·Oncogene·M Barkett, T D Gilmore
Dec 22, 1999·Oncogene·B Rayet, C Gélinas
Sep 13, 2000·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·R C BaxterJ L Martin
Feb 13, 2001·Nucleic Acids Research·P RenardJ Remacle
Jun 5, 2001·Apoptosis : an International Journal on Programmed Cell Death·A J Butt, A C Williams
May 11, 2002·Nature Reviews. Cancer·Michael KarinZhi-Wei Li
Mar 12, 2003·Toxicology Letters·Marion MacFarlane
Mar 26, 2003·Cell Death and Differentiation·H N LeBlanc, A Ashkenazi
Oct 17, 2003·Genes & Development·Jerry M Adams
Jan 28, 2004·Cell·Nika N Danial, Stanley J Korsmeyer
Jan 31, 2004·The Journal of Biological Chemistry·Patricia Rouet-BenzinebAndré Bado
Nov 13, 2004·Cell Research·Fiona C Kimberley, Gavin R Screaton

❮ Previous
Next ❯

Citations

Aug 6, 2013·Animal Reproduction Science·I GunaretnamR Rajamahendran
Dec 23, 2008·Molecular & Cellular Proteomics : MCP·Rod K NibbeMark R Chance
Dec 17, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Charles S FuchsMichael Pollak
Jul 18, 2009·American Journal of Respiratory and Critical Care Medicine·Kristen L VeraldiCarol A Feghali-Bostwick
Jul 23, 2013·Investigative Ophthalmology & Visual Science·Qiuhua ZhangJena J Steinle
May 24, 2008·BMC Cancer·Temitope O KekuPauline K Lund
May 30, 2009·Endocrine Reviews·Sherryline Jogie-BrahimYoungman Oh
Jun 24, 2014·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Michael A Johnson, Sue M Firth
Aug 16, 2008·International Journal of Colorectal Disease·Liang QiaoBenjamin C Y Wong
Jun 18, 2011·Cellular Oncology (Dordrecht)·Sandra Pérez-TorrasAdela Mazo
Jan 2, 2008·Biochimica Et Biophysica Acta·A M JoshuaJ A Squire
Aug 28, 2007·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Peng FangRon G Rosenfeld
Sep 3, 2009·Annals of the New York Academy of Sciences·Amandine PlantivauxLaurence Egan
Jan 16, 2013·International Journal of Cancer. Journal International Du Cancer·Gong YangJinsong Liu
Aug 9, 2011·Mechanisms of Ageing and Development·Lucia MicutkovaPidder Jansen-Duerr
Dec 1, 2009·Biochemical and Biophysical Research Communications·Hyeok-Ran KwonSang-Muk Oh
Mar 20, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Ya-Mei DangXiao-Dong Xie
Aug 25, 2016·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Hae-Ki MinArun J Sanyal
Aug 2, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Gang HuangXiao-Dong Xie
Jun 3, 2021·International Journal of Molecular Sciences·Cecilia Fernández-PonceElkin Navarro Quiroz
Jun 3, 2021·International Journal of Molecular Sciences·Helena OliveresJoan Maurel
Nov 27, 2021·Expert Opinion on Biological Therapy·Motoshi KozakaiAkihiko Usui

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis