Insulin-like growth factor binding protein 7, a member of insulin-like growth factor signal pathway, involved in immune response of small abalone Haliotis diversicolor

Fish & Shellfish Immunology
Na LiYilei Wang

Abstract

Insulin-like growth factor binding protein 7 (IGFBP7), the only member of the IGFBP superfamily that binds strongly to insulin, may have different functions from other IGFBPs. Unlike other IGFBPs, there is no knowledge available on aquatic invertebrate IGFBP7. In this study, a molluscan IGFBP7 gene, saIGFBP7, was cloned for the first time from the small abalone Haliotis diversicolor. Its full-length cDNA sequence is 1812 bp, with a 720 bp open reading frame encoding a protein of 239 aa. The molecular mass of the deduced protein is approximately 25.37 kDa with an estimated pI of 5.00, and it shares highest 41% identity to IGFBP7 of Amblyomma americanum. Analysis of conserved domains revealed the presence of an IGFBP N-terminal domain (IB), a kazal-type serine proteinase inhibitor domain (KI), and an immunoglobulin-like C2 domain (IgC2) in saIGFBP7. Furthermore, the 12 cysteine residues and the signature amino acid motif 'xCGCCxxC' which are characterized by the amino terminus region of the IGFBP superfamily are all presented in saIGFBP7. Quantitative real-time PCR and western blot were employed to investigate the tissue distribution of saIGFBP7, and its expression under bacterial challenge. The saIGFBP7 mRNA and protein could be...Continue Reading

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Citations

Oct 16, 2013·Zoological Science·Toshie MatsumotoMasahiko Awaji
Feb 12, 2014·Clinica Chimica Acta; International Journal of Clinical Chemistry·Shuzhen ZhuMaode Lai
Oct 23, 2016·Fish & Shellfish Immunology·Xiaoshuai HuangJ Sook Chung
Feb 2, 2021·PeerJ·Tiranan BuddawongWattana Weerachatyanukul
Nov 19, 2018·General and Comparative Endocrinology·Benjamin HerranPierre Grève
May 15, 2021·Fish Physiology and Biochemistry·S ChandhiniV J Rejish Kumar

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