PMID: 7524698Aug 1, 1994Paper

Insulin-like growth factor binding proteins show distinct patterns of expression in the rat uterus

Biology of Reproduction
M R GirvigianG F Erickson

Abstract

An intrinsic insulin-like growth factor (IGF) system, complete with IGF ligands, receptors, and biological responses, is present in the rat uterus, where it is thought to regulate uterine homeostasis by autocrine/paracrine mechanisms. It is known that IGF binding proteins (IGFBP) modulate IGF-I and IGF-II action, but very little information is available concerning their cellular localization in the uterus. Therefore, we have employed in situ hybridization to localize IGFBP-1, -2, -3, -4, -5, and -6 mRNAs in the adult rat uterus during the estrous cycle. IGFBP-1 was undetectable in all uteri examined. IGFBP-2 mRNA was localized only in the luminal epithelium of the endometrium. It was abundant during proestrus (P1000 h, P2000 h) and early estrus (E0200 h), but was relatively low at other stages of the cycle. IGFBP-3 mRNA was localized to the stroma cells juxtaposed to the endometrium. A weak signal was detected on estrus morning (E0200 h, E1000 h), but high levels of IGFBP-3 mRNA were observed in the stroma cells on Day 12 of pregnancy. IGFBP-4 mRNA was localized only in the luminal epithelium of the endometrium. It was moderately abundant at diestrus I and II, but the signal was very low or absent at other times in the cycle. I...Continue Reading

Citations

Jul 1, 1996·Molecular and Cellular Endocrinology·S SongF A Simmen
Jan 1, 1995·Progress in Growth Factor Research·P L Kaye, M B Harvey
Jan 1, 1995·Progress in Growth Factor Research·J E PintarB Green
Jun 1, 1997·Theriogenology·A HerrlerH M Beier
Aug 29, 1998·Molecular and Cellular Endocrinology·M van KleffensS L Drop
Jun 13, 2003·Biology of Reproduction·Xuxia WuAmilcar Flores-Morales
Apr 23, 2008·Laboratory Investigation; a Journal of Technical Methods and Pathology·Adrienne S McCampbellPeter J A Davies
Feb 23, 2005·The Journal of Reproduction and Development·Ayako InoueSumio Takahashi

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