PMID: 9446837Mar 7, 1998Paper

Insulin-like growth factor-I and II receptor expression in rat colon mucosa are affected by dietary lipid intake

The Journal of Nutrition
W ZhangR S MacDonald

Abstract

Epidemiologic data and animal models have demonstrated a correlation between dietary fat composition and colon cancer risk. We have previously found that dietary fat alters cell proliferation in rat colon, which may influence the risk of colon cancer. Growth factors, including insulin-like growth factor (IGF) I and II, regulate the cell cycle in most mammalian tissues. Hence, we measured IGF-I and IGF-II receptor expression in colonocytes from Sprague-Dawley rats fed diets containing either beef tallow (BT) or corn oil (CO) at 12, 30 or 37% of energy for 4 wk. Quantitative reverse transcriptase polymerase chain reaction (RT-PCR) using an internal standard was used to examine the relative expression of both IGF-I and II receptor mRNA in three sections of the colon. The IGF-I receptor protein was also measured by Western immunoblot. In the distal colon, IGF-I receptor gene expression and protein increased significantly as the percentage of CO increased. In both proximal and middle colon, an increased percentage of BT resulted in significantly increased IGF-II receptor expression. In the proximal colon, IGF-II receptor expression decreased with increasing CO concentration, whereas in the middle colon, rats fed 37% CO had significa...Continue Reading

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Citations

Feb 3, 2007·International Journal of Cancer. Journal International Du Cancer·Tetsuya OtaniUNKNOWN Japan Public Health Center-based Prospective Study Group
Apr 2, 2011·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Hiroshi NotoMitsuhiko Noda
Oct 3, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·V G KaklamaniC S Mantzoros
Jul 12, 2017·Oncology Letters·Eriko TanabeHiroki Kuniyasu
Jun 2, 2009·Archives of Physiology and Biochemistry·Hila SetiHaim Werner
Apr 14, 2015·BioMed Research International·Varsha P BrahmkhatriHanudatta S Atreya

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