PMID: 11903419Mar 21, 2002Paper

Insulin-like growth factor I, epidermal growth factor and transforming growth factor beta expression and their association with intrauterine fetal growth retardation, such as development during human pregnancy

Diabetes, Obesity & Metabolism
M Hernandez-ValenciaM De Jesus Ortiz

Abstract

Fetal intrauterine growth retardation (IUGR) is one of the most common obstetric problems, with a frequency of 12% in Mexico. In the past, investigations have focused on extrinsic causes of IUGR. More recent studies have examined the intrinsic factors that cause fetal intrauterine growth. Maintenance of fetal growth has been attributed to insulin-like growth factor (IGF), epidermal growth factor (EGF) and transforming growth factor beta (TGF-beta). The objective of this study was to assess the levels of these growth factors during pregnancy and to determine whether or not low concentrations are associated with IUGR. Nine women whose pregnancies were complicated by IUGR and a group of nine women whose pregnancies exhibited normal fetal intrauterine growth were studied. IUGR was determined by sonography and confirmed by weight at birth. Venous blood samples were taken from both groups of pregnant women at the end of each trimester. Enzyme-linked immunosorbent assays, immunoradiometric assays and radioimmunoassays were used to process samples, and the results were analysed by anova. IGF-I levels increased in both groups during pregnancy, but the increase was lower (p < 0.001) in the IUGR group throughout pregnancy and at delivery....Continue Reading

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Citations

Jan 22, 2009·Endocrine·Svetozar S DamjanovicBojana M Popovic
Apr 27, 2005·Archives of Disease in Childhood·S JarvisUNKNOWN SCPE collaboration of European Cerebral Palsy Registers
Dec 19, 2013·BioMed Research International·Mandeep SinghJustin C Konje
Oct 1, 2014·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Attila RabJózsef Gábor Joó
Feb 10, 2016·Frontiers in Physiology·Kris Genelyn DimasuayThomas Jansson
Jun 22, 2007·Placenta·H N JonesT Jansson
Jun 12, 2013·Acta Obstetricia Et Gynecologica Scandinavica·Agzail S A Elhddad, Hany Lashen
Sep 15, 2006·Archives of Medical Research·Marcelino Hernandez-Valencia, Mary-Elizabeth Patti
Nov 1, 2016·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Tina StormMette Madsen
Jan 26, 2006·Endocrine Reviews·Vanessa E MurphyVicki L Clifton
Mar 3, 2020·Nutrition Research Reviews·Ericka Moreno-MendezMaria-Luisa Lazo-de-la-Vega-Monroy

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