Insulin-like growth factor-I expression during early conceptus development in the pig.

Biology of Reproduction
R LetcherF A Simmen

Abstract

Porcine conceptuses (embryo and associated membranes) in utero undergo developmental morphological transformations coincident with structural and biochemical changes in the uterine endometrium during early gestation. To elucidate a possible role for insulin-like growth factor-I (IGF-I) in these events, porcine endometrial (Days 8, 10, 11, 12, 14, and 30) and conceptus (Days 12, 14, and 16) tissues were characterized for the presence of IGF-I peptide and mRNAs. The corresponding uterine luminal fluids (ULF) at these stages of pregnancy were also analyzed for immunoreactive IGF-I concentration. ULF IGF-I was lowest on Day 8, highest on Day 12, and declined by Day 14. In contrast, endometrial tissue IGF-I content remained constant during this period. Conceptus tissues contained less IGF-I than endometrial tissues; however, conceptus IGF-I values were maximum on Day 12 coincident with peak values for ULF IGF-I. Dot-blot hybridization analyses revealed temporal variation in steady-state levels of IGF-I mRNAs in endometrium. Highest levels of endometrial IGF-I mRNA were detected on Day 12 and were about 4-fold greater than on Day 30 of pregnancy. IGF-I mRNA expression in conceptus tissues on Days 12, 14, and 16 was the same and was s...Continue Reading

Citations

Aug 1, 1993·Molecular Reproduction and Development·G A SchultzM Harvey
Jan 22, 2003·Animal Reproduction Science·S Schäfer-Somi
Dec 1, 1991·Baillière's Clinical Endocrinology and Metabolism·D R Brigstock
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Nov 3, 2009·Molecular Human Reproduction·Fuller W BazerKayla Bayless
Jan 1, 1991·Annals of the New York Academy of Sciences·F W BazerF A Simmen
Sep 11, 2012·Journal of Animal Science and Biotechnology·Fuller W BazerGuoyao Wu
Sep 27, 2005·Reproduction : the Official Journal of the Society for the Study of Fertility·M D AshworthR D Geisert
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Jan 28, 2020·Reproduction in Domestic Animals = Zuchthygiene·Lola Llobat
Jul 4, 2021·Scientific Reports·Ewelina Goryszewska-SzczurekAgnieszka Waclawik

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