PMID: 8614286Jan 1, 1996Paper

Insulin-like growth factor-I given subcutaneously reduces clinical deficits, decreases lesion severity and upregulates synthesis of myelin proteins in experimental autoimmune encephalomyelitis

Life Sciences
D L YaoH D Webster

Abstract

To extend our evaluation of insulin-like growth factor-1 (IGF-1) treatment for human demyelinating diseases, we compared effects of s.c. and i.v. IGF-1 in an in vivo model with lesions resembling those seen in multiple sclerosis. Experimental autoimmune encephalomyelitis (EAE) was induced in Lewis rats with an emulsion containing guinea pig spinal cord and treatment with placebo or with s.c. or i.v. IGF-1 was started when definite clinical weakness was present. IGF-I given subcutaneously significantly reduced clinical deficits and lesion severity. The clinical improvement, as measured by clinical deficit scores, stride lengths and exercise wheel rotations, was evident in 48 hrs and was comparable to that produced by the same IGF-I dose administered intravenously. Subcutaneously administered IGF-I also increased relative mRNA levels of myelin basic protein (MBP), proteolipid (PLP) and 2',3' cyclic nucleotide 3'-phosphodiesterase (CNP), thereby promoting myelin regeneration. We conclude that s.c. IGF-I produces dramatic improvement in acute, demyelinating EAE. Our results also suggest that this growth factor may be useful in treating multiple sclerosis patients with active demyelination.

References

Mar 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·S KomolyC A Bondy
Feb 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·F A McMorrisR W Furlanetto
Jun 20, 1995·Proceedings of the National Academy of Sciences of the United States of America·D L YaoH D Webster
Apr 1, 1994·Annals of Internal Medicine·C A BondyM Skarulis
Aug 27, 1993·Annals of the New York Academy of Sciences·D B Stong, R Raskin
Feb 1, 1994·Clinical and Experimental Immunology·K RobbinsP Jardieu
Aug 1, 1993·The Journal of Clinical Investigation·R ClarkP Jardieu

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Citations

Mar 20, 2002·Current Neurology and Neuroscience Reports·S Markovic-Plese, H F McFarland
Aug 21, 2013·CNS Drugs·Amir-Hadi MaghziEmmanuelle Waubant
Jan 1, 1997·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·W Zumkeller
Oct 29, 2002·Trends in Immunology·Richard M RansohoffMoses Rodriguez
Nov 27, 1997·The New England Journal of Medicine·R A RudickR M Ransohoff
Aug 26, 1998·Proceedings of the National Academy of Sciences of the United States of America·B CannellaC S Raine
Apr 13, 2004·Neuroreport·Daniel ChesikJacques De Keyser
Dec 22, 1999·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·N Scolding
Jan 19, 2008·Sports Medicine·Lesley J White, Vanessa Castellano
Aug 29, 1998·Molecular and Cellular Endocrinology·P D GluckmanA Gunn
Feb 4, 2010·Pharmacology & Therapeutics·Anneke Van der WaltTrevor Kilpatrick
Mar 14, 2007·Journal of Neurochemistry·Qiao-Ling Cui, Guillermina Almazan
Sep 22, 2010·Journal of Neuroscience Research·Craig S MooreStephen J Crocker
Mar 27, 2016·Experimental Neurology·Yangyang Huang, Cheryl F Dreyfus
May 29, 2007·International Review of Neurobiology·Daniel ChesikJacques De Keyser
Apr 2, 2017·Neuroscience Letters·Martin HlavicaBenjamin V Ineichen
Apr 1, 1997·Multiple Sclerosis : Clinical and Laboratory Research·H D Webster
Apr 9, 2002·Multiple Sclerosis : Clinical and Laboratory Research·J A FrankT Leist
Sep 1, 2005·Endocrine Reviews·V C RussoG A Werther
Jul 20, 2000·Journal of Neuropathology and Experimental Neurology·J W RussellD Golovoy
Apr 23, 2020·Frontiers in Cellular Neuroscience·Elisabeth TraiffortYousra Laouarem
Apr 19, 2005·Journal of Child Neurology·Raili Riikonen, Ursula Turpeinen
Mar 7, 2021·Biomolecules·Jocelyn M BretonDaniela Kaufer
May 29, 2021·Translational Neuroscience·Majid GhareghaniKazem Zibara

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