Insulin-like growth factor I (Igf-1) gene polymorphism in patients with non-metastatic breast cancer

Gene
Arzu YarenGamze Gokoz Dogu

Abstract

We aimed to assess the association between IGF-I gene (CA repeats) polymorphism in breast cancer patients and their clinicopathological features, as well as disease recurrence and survival. Seventy-six non-metastatic breast cancer patients were enrolled in the present study. The IGF-I (CA) repeats were studied with polymerase chain reaction by using proper primers belonging to these gene areas from DNA samples. Results show that the non 19- non 19 homozygote were more common in patients without lymph node involvement (p=0.04), with low histological grade (p=0.04), with positive hormone receptor status (p=0.01), and in patients without recurrence (p=0.06). These results suggest that the non 19-non 19 carriers have some favorable prognostic factors, and IGF-I gene polymorphism (CA repeats) may affect disease recurrence and overall survival.

References

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Citations

Mar 10, 2015·Molecular Cancer·Panagiotis F ChristopoulosMichael Koutsilieris
Dec 8, 2016·Anais Da Academia Brasileira De Ciências·Danylo R Costa-SilvaBenedito B DA Silva

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