Insulin-like growth factor-I (IGF-I) and its association with lymphocyte homeostasis in the ageing cat

Mechanisms of Ageing and Development
D J CampbellB M Hannigan

Abstract

Ageing affects feline lymphocyte homeostasis in a similar pattern to that observed in other long-lived mammalian species, contributing to increased levels of morbidity and mortality in the ageing cat. Insulin-like growth factor-I (IGF-I) is now recognised as an important endocrine regulator of immunity and has been shown to decline with age in humans and rodent species. Analysis of plasma IGF-I in adult and senior cats confirmed that the older cats had significantly lower circulating levels of IGF-I. In order to determine whether an association existed between lymphocyte subpopulations and IGF-I levels in the cat, each parameter was measured and subjected to regression analysis. A highly significant association was found in vivo between plasma IGF-I and CD4(+) T-cell values in the senior group, but no such association was observed in the adult group. In order that this relationship could be examined further, in vitro studies were undertaken to investigate the effects of physiologically relevant concentrations of recombinant human IGF-I (rhIGF-l) on peripheral blood lymphocyte (PBL) cultures from adult and senior cats. While rhlGF-I induced low-level thymidine incorporation in the lymphocytes isolated from the senior group, it d...Continue Reading

Citations

Sep 4, 2009·Rejuvenation Research·Johannes HoferMartina Prelog
Sep 8, 2010·Toxicon : Official Journal of the International Society on Toxinology·Thatiane C AntunesMarcelo L Santoro
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