Abstract
It has been shown that prophylactic exogenous insulin treatment prevents the development of insulin-dependent diabetes mellitus (IDDM) in animal models and humans. In this study, we examined whether the development of diabetes and insulitis in female non-obese diabetic (NOD) mice could be affected by prophylactic administration of insulin-like growth factor I (IGF-I), which shares structural homology with insulin and has insulin-like metabolic effects. Two experiments which differed in duration and dosage of IGF-I treatment were carried out. In the first experiment, animals were treated from 4 to 9 weeks of age with IGF-I (17.9 nmol/day at 4-5 weeks of age and 35.9 nmol/day at 6-9 weeks of age) and observed up to 34 weeks of age. In the second experiment, the animals were treated from 4 to 34 weeks of age with IGF-I (1.79 nmol/day at 4-5 weeks of age, 3.59 nmol/day at 6-9 weeks of age, and 5.38 nmol/day at 10-34 weeks of age). The former treatment could significantly delay the onset of diabetes (P < 0.05) and decrease the insulitis score at 10 weeks of age (P < 0.01). On the other hand, the latter treatment did not affect the incidence of diabetes, the age at onset or the insulitis score. Our results suggest that the IGF-I trea...Continue Reading
References
Nov 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·Z J ZhangH L Weiner
Aug 1, 1990·Diabetes·M A AtkinsonR Luchetta
Mar 2, 1989·The New England Journal of Medicine·S C ShahN E Simpson
May 22, 1986·The New England Journal of Medicine·G S Eisenbarth
Dec 1, 1985·Diabetologia·C F GotfredsenE K Frandsen
Sep 1, 1994·Diabetologia·E R Froesch, M Hussain
Feb 1, 1995·The Journal of Clinical Investigation·A MuirN Maclaren
Apr 10, 1993·Lancet·R J KellerR A Jackson
Jan 1, 1994·Annals of Internal Medicine·J W Kolaczynski, J F Caro
Citations
Sep 1, 2005·Diabetologia·J StørlingT Mandrup-Poulsen
Aug 22, 2007·Cell Biochemistry and Biophysics·Jun-Li Liu
Jul 27, 2001·Diabetes Technology & Therapeutics·K M Thrailkill
Jul 2, 2004·ILAR Journal·Françoise Homo-Delarche
Apr 9, 1999·Acta Paediatrica. Supplement·K KidaK Nakamura
May 8, 2002·The Journal of Clinical Investigation·Mónica GeorgeFatima Bosch
Nov 25, 2004·Diabetes·Yarong LuJun-Li Liu
Feb 15, 2001·Gene Therapy·N GiannoukakisP Robbins
Mar 21, 2007·Expert Reviews in Molecular Medicine·James R Goss
Feb 14, 2008·American Journal of Physiology. Endocrinology and Metabolism·Katie RobertsonJun-Li Liu
Oct 24, 2014·EMBO Molecular Medicine·Daniel BilbaoNadia Rosenthal
Dec 29, 2004·Autoimmunity·Keiichi KodamaTakao Saruta
Jun 27, 1998·Journal of Pediatric Endocrinology & Metabolism : JPEM·Y KainoK Kida
Jul 7, 1999·Journal of Pediatric Endocrinology & Metabolism : JPEM·N MatsuuraT Hotsubo
Feb 26, 2000·Journal of Pediatric Endocrinology & Metabolism : JPEM·H HiraiK Kida
Jun 6, 2018·Frontiers in Endocrinology·Luz AndreoneMarcelo J Perone
Jul 17, 2020·Artificial Organs·Liang ZhangZhiwei Wang
Aug 1, 2021·Life Sciences·Xiaoxiao ZhuLanlan Zhou