Insulin-like growth factor I (IGF-I) enhances hyaluronic acid synthesis in rabbit pericardium.

Biochimica Et Biophysica Acta
A HondaY Mori

Abstract

We examined which substances stimulate hyaluronic acid synthesis in rabbit pericardium and pericardial cells. (1) The addition of 10% (v/v) pericardial fluid to the incubation medium of the pericardium enhanced hyaluronic acid synthesis to about 2.5-times over the control, suggesting that there were some stimulating factors of the hyaluronic acid synthesis in the pericardial fluid. (2) The addition of 100 ng/ml insulin-like growth factor-I (IGF-I) to the incubation medium caused an approx. 2-fold increase of hyaluronic acid synthesis over the control in the pericardium. (3) IGF-I stimulated the hyaluronic acid synthesis in pericardial cells in a dose-dependent manner, but did not significantly stimulate the sulfated glycosaminoglycan synthesis. (4) The increase in the hyaluronic acid synthesis induced by IGF-I (100 ng/ml) or pericardial fluid was blocked by the copresence of monoclonal anti-IGF-I antibody. (5) IGF-I caused possible induction of the hyaluronic acid synthase activity and general protein and RNA synthesis before the initiation of DNA synthesis in pericardial cells. These results suggest a new biological action of IGF-I that stimulates hyaluronic acid synthesis in pericardium or the pericardial cavity of heart.

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Citations

Sep 20, 2001·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·R A SaxerA J Nixon
Sep 10, 2009·The Journal of Biological Chemistry·Davide VigettiAlberto Passi
Apr 20, 2005·The Journal of Experimental Medicine·Julie M JamesonWendy L Havran
Apr 1, 1992·In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association·J HitzemanH L Hosick
May 29, 2012·Best Practice & Research. Clinical Endocrinology & Metabolism·Terry J SmithRaymond S Douglas
Jun 1, 1993·Journal of Biomedical Materials Research·D SimionescuR Deac
Jan 20, 2019·Basic Research in Cardiology·Fábio TrindadeInês Falcão-Pires
Mar 9, 2021·Bio-medical Materials and Engineering·Dilek Sönmezerİsmail Alper İşoğlu

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