Insulin-like growth factor I (IGF-I) regulates IGF binding protein-5 gene expression in the brain

Endocrinology
P Ye, J D'Ercole

Abstract

Insulin-like growth factor (IGF-I) plays an important role during brain development. IGF binding protein-5 (IGFBP-5) is known to be capable of modulating IGF-I actions and is expressed in brain during development. To begin to investigate the interaction between IGF-I and IGFBP-5 in brain, we asked whether IGF-I influences the brain expression of IGFBP-5. We quantified IGFBP-5 expression in multiple brain regions of two lines of IGF-I transgenic (Tg) mice that exhibit distinctive patterns of brain transgene expression. MT-I/IGF-I Tg mice carry a transgene driven by metallothionein-I (MT-I) promoter and exhibit highest levels of transgene expression in cerebral cortex, whereas in IGF-II/IGF-I Tg mice the mouse IGF-II promoter drives the transgene and the expression is highest in the cerebellum. In normal adult mice, IGFBP-5 messenger RNA (mRNA) was detected in all brain regions examined, and the highest levels of the mRNA were found in cerebellum, followed by brainstem, diencephalon, hippocampus, and cerebral cortex. Compared to these littermate controls, IGFBP-5 mRNA abundance was increased in both lines of Tg mice. In MT-I/IGF-I Tg mice, cerebral cortex had the greatest increase (approximately 200%), whereas cerebella of IGF-II...Continue Reading

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Citations

Jan 25, 2008·Proceedings of the National Academy of Sciences of the United States of America·Jennifer R GatchelHuda Y Zoghbi
Apr 12, 2012·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Yusuke HigashiPatrice Delafontaine
May 18, 2010·American Journal of Physiology. Heart and Circulatory Physiology·Cheryl A ConoverMichael T Overgaard
Dec 2, 2011·PloS One·Alex F BokovArlan Richardson
May 13, 2014·Experimental Gerontology·Sara L Harstad, Cheryl A Conover
Jan 15, 2010·Trends in Endocrinology and Metabolism : TEM·Yusuke HigashiPatrice Delafontaine
Jun 9, 2007·Molecular and Cellular Endocrinology·Junko TanakaHideko Sone
Feb 27, 2010·Developmental Neurobiology·Ignacio Torres-Aleman
Nov 19, 2005·Experimental Neurology·Marcelo E EzquerAlicia M Seltzer
Oct 3, 2002·Neuropeptides·A Joseph D'ErcoleJohn R O'Kusky
Jul 12, 2002·Glia·Steven L O'DonnellTeresa L Wood
Mar 25, 2010·The Journal of Clinical Endocrinology and Metabolism·G BinderA R Franz
Feb 28, 2002·Endocrinology·Robin VargheseGabriel E Dimattia
Apr 14, 2015·BioMed Research International·Varsha P BrahmkhatriHanudatta S Atreya
Sep 1, 2005·Endocrine Reviews·V C RussoG A Werther

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