Insulin-like growth factor I is an afferent trophic signal that modulates calbindin-28kD in adult Purkinje cells

Journal of Neuroscience Research
M P Nieto-BonaI Torres-Aleman

Abstract

Recent evidence suggests that Purkinje cells are specific targets of insulin-like growth factor I (IGF-I) through their entire life span. During development, Purkinje cell numbers and their calbindin-28kD content increase after IGF-I treatment in culture. In the adult, part of the IGF-I present in the cerebellum is transported from the inferior olive, and modulates Purkinje cell function. We investigated whether IGF-I produced by inferior olive neurons and transported to the contralateral cerebellum through climbing fibers may modulate the levels of calbindin-28kD in the cerebellum of adult animals. Twenty-four hr after injection of an antisense oligonucleotide of IGF-I into the inferior olive, both IGF-I and calbindin-28kD levels in the contralateral cerebellar lobe were significantly reduced, while the number of calbindin-positive Purkinje cells was unchanged. The effect of the antisense on IGF-I levels was fully reversed 3 days after its injection into the inferior olive, with a postinhibitory rebound observed at this time, while calbindin-28kD levels slowly returned to control values. A control oligonucleotide did not produce any change in either IGF-I or calbindin-28kD content in the cerebellum. These results indicate that...Continue Reading

References

Oct 21, 1991·Brain Research. Developmental Brain Research·S PonsI Torres-Aleman
Nov 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·S PåhlmanI Johansson
Mar 1, 1988·Trends in Neurosciences·D G BaskinD M Dorsa
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Jan 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·P RotweinJ E Krause
Dec 1, 1993·Journal of Neuroscience Research·M P Nieto-BonaI Torres-Aleman
Oct 11, 1994·Proceedings of the National Academy of Sciences of the United States of America·M A Castro-Alamancos, I Torres-Aleman
Aug 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·M A Castro-Alamancos, I Torres-Aleman
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Citations

Mar 1, 1996·Annals of Neurology·I Torres-AlemanJ Berciano
Dec 1, 1996·Molecular Neurobiology·A J D'ErcoleG Gutierrez-Ospina
Nov 14, 2000·Neuroscience·D L Tolbert, B R Clark
Mar 14, 1998·Proceedings of the National Academy of Sciences of the United States of America·A M FernandezI Torres-Aleman
Dec 4, 2012·Molecular and Cellular Neurosciences·C LebrunI Dusart
Mar 26, 2004·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Yan LiuSylvia Christakos
Dec 24, 1997·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·M P Nieto-BonaI Torres-Alemán

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