PMID: 7540112Mar 1, 1995Paper

Insulin-like growth factor I is involved in inflammation linked angiogenic processes after microembolisation in porcine heart

Cardiovascular Research
A KlugeW Schaper

Abstract

Angiogenesis in the porcine heart can be induced by myocardial ischaemia following vascular occlusions. This process is characterised by increased numbers of monocytes/macrophages, known to be potent producers of various mitogens such as insulin-like growth factors (IGF) and interleukins (IL). The aim of the study was to examine gene expression of these factors by means of northern blot hybridisation, slot blot analysis, and in situ hybridisation in a porcine model of coronary angiogenesis. Experimental ischaemia and subsequent focal necroses were induced by selective injection of 25 microns microspheres into the left circumflex artery. The hearts were excised after 3-168 h of microembolisation, and tissue was collected from a non-ischaemic control area and the circumflex region of the same heart for further analysis. IGF-I was constitutively transcribed in normal porcine myocardium mainly by myocytes. Following microembolisation, IGF-I mRNA expression was significantly increased in the experimental region (1.8-fold) after 72 h and to a lesser extent after 168 h. In the ischaemic region, characterised by capillary sprouting, numerous mononuclear cells contained IGF-I mRNA. In contrast, IGF-II mRNA levels, constitutively produce...Continue Reading

Citations

Sep 5, 2015·Archives of Gynecology and Obstetrics·Nikolaos VrachnisGeorge Creatsas
Jul 20, 2012·The Journal of Investigative Dermatology·Elaine EmmersonMatthew J Hardman
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