Insulin-like growth factor I is required for vessel remodeling in the adult brain

Proceedings of the National Academy of Sciences of the United States of America
C Lopez-LopezI Torres-Aleman

Abstract

Although vascular dysfunction is a major suspect in the etiology of several important neurodegenerative diseases, the signals involved in vessel homeostasis in the brain are still poorly understood. We have determined whether insulin-like growth factor I (IGF-I), a wide-spectrum growth factor with angiogenic actions, participates in vascular remodeling in the adult brain. IGF-I induces the growth of cultured brain endothelial cells through hypoxiainducible factor 1 alpha and vascular endothelial growth factor, a canonical angiogenic pathway. Furthermore, the systemic injection of IGF-I in adult mice increases brain vessel density. Physical exercise that stimulates widespread brain vessel growth in normal mice fails to do so in mice with low serum IGF-I. Brain injury that stimulates angiogenesis at the injury site also requires IGF-I to promote perilesion vessel growth, because blockade of IGF-I input by an anti-IGF-I abrogates vascular growth at the injury site. Thus, IGF-I participates in vessel remodeling in the adult brain. Low serum/brain IGF-I levels that are associated with old age and with several neurodegenerative diseases may be related to an increased risk of vascular dysfunction.

Associated Clinical Trials

Jan 29, 2013·Mustafa Sahin, Mustafa Sahin

References

Jul 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·J E BlackW T Greenough
Feb 1, 1995·Endocrine Reviews·J I Jones, D R Clemmons
Dec 1, 1996·Molecular Neurobiology·A J D'ErcoleG Gutierrez-Ospina
Jul 23, 1998·Journal of Microscopy·M G Reed, C V Howard
Apr 28, 1999·Journal of Neuropathology and Experimental Neurology·K H Plate
May 5, 1999·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·I Torres-Aleman
Jun 9, 1999·Proceedings of the National Academy of Sciences of the United States of America·K SjögrenC Ohlsson
Jun 23, 1999·Proceedings of the National Academy of Sciences of the United States of America·S YakarD LeRoith
Apr 6, 2000·Journal of Applied Physiology·G L Semenza
Sep 13, 2000·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·G McGauley
Sep 13, 2000·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·B A Bengtsson
Sep 13, 2000·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·S E Dunn
May 31, 2001·Molecular Neurobiology·I Torres-Aleman
Apr 24, 2002·Seminars in Cell & Developmental Biology·Patrick H Maxwell, Peter J Ratcliffe
Jul 11, 2002·The Journal of Clinical Endocrinology and Metabolism·Ann HellströmZvi Laron
Nov 5, 2002·Nature Medicine·E CarroI Torres-Aleman

❮ Previous
Next ❯

Citations

Dec 31, 2009·Cellular and Molecular Neurobiology·I Lista, G Sorrentino
Jul 27, 2007·Reviews in Endocrine & Metabolic Disorders·Thomas J McDonaldPeter W Nathanielsz
Nov 14, 2007·Neuromolecular Medicine·Marcelo O DietrichIgnacio Torres-Aleman
Feb 21, 2008·Neuromolecular Medicine·M Llorens-MartínJosé L Trejo
Nov 2, 2011·Journal of the International Neuropsychological Society : JINS·Laura ChaddockArthur F Kramer
Mar 15, 2006·Nature Neuroscience·Alexis M StranahanElizabeth Gould
Mar 23, 2006·Nature Reviews. Neuroscience·Mark P Mattson, Tim Magnus
Dec 21, 2007·Nature Reviews. Neuroscience·Charles H HillmanArthur F Kramer
Mar 21, 2012·Nature Reviews. Neuroscience·Ana M Fernandez, Ignacio Torres-Alemán
Mar 28, 2012·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Zoltan Ungvari, Anna Csiszar
Nov 9, 2011·The Neurologist·Fernando Alonso-FrechAmelia Mendoza Rodriguez
Apr 30, 2011·Journal of Applied Physiology·Michelle W VossArthur F Kramer
Dec 23, 2011·Molecular Cancer Therapeutics·Hemant K BidPeter J Houghton
Aug 10, 2010·Developmental Neuroscience·Laura ChaddockArthur F Kramer
Nov 15, 2012·Journal of Translational Medicine·Juan E Puche, Inma Castilla-Cortázar
Oct 9, 2012·Molecular Neurodegeneration·Carolina FrancoIgnacio Torres-Alemán
Nov 30, 2010·Journal of Angiogenesis Research·Eugen B PetcuMaria M Opris
Jul 11, 2009·Endocrine Reviews·Claes OhlssonJohan Svensson
May 29, 2010·Medicine and Science in Sports and Exercise·Laura ChaddockNeal J Cohen
Sep 24, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Henriette van PraagFred H Gage
Oct 17, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Marcelo O DietrichTamas L Horvath
Jul 14, 2011·The Journal of Endocrinology·Han YanWilliam E Sonntag
Jul 13, 2006·The Keio Journal of Medicine·Eva Carro, Ignacio Torres-Aleman
Aug 6, 2013·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·L XieC Li
May 27, 2014·Archives of Gerontology and Geriatrics·Thays Martins VitalRuth Ferreira Santos-Galduróz
Aug 12, 2014·Cardiology Research and Practice·Rebecca A Gary, Kathryn Brunn
Feb 21, 2008·Neuromolecular Medicine·Henriette van Praag
Sep 14, 2013·Trends in Cognitive Sciences·Michelle W VossHenriette van Praag
Mar 24, 2016·Journal of the Neurological Sciences·Paula Grazielle Chaves da SilvaClynton Lourenço Correa
Sep 4, 2012·Progress in Neurobiology·Inês Marques-AleixoAntónio Ascensão
Dec 14, 2011·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Eric P PrinssenCeline Risterucci
Aug 26, 2011·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·S SaengerF Metzger
Jul 16, 2011·Translational Research : the Journal of Laboratory and Clinical Medicine·Naoaki HaradaKenji Okajima

❮ Previous
Next ❯

Related Concepts

Related Feeds

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.