Insulin-like growth factor-I raises serum procollagen levels in children and adults with Laron syndrome

Clinical Endocrinology
B KlingerZ Laron

Abstract

Recombinant IGF-I is now available for the treatment of GH insensitivity (Laron syndrome). We have determined the effects of IGF-I on soft connective tissue and bone metabolism in a group of patients with this disorder. Thirteen patients with Laron syndrome (LS) (8 children and 5 adults) were included in the study. The children with LS were treated with IGF-I for 3 years with daily doses of 150-200 micrograms/kg. The adult LS patients were treated for 9 months with daily doses of 50-120 micrograms/kg. Blood samples for procollagens were collected before, during and at the end of IGF-I treatment. Serum levels of the carboxyterminal propeptide of type I procollagen (PICP), the aminoterminal propeptide of type III procollagen (PIIINP) and of the pyridinoline cross-linked carboxyterminal telopeptide of type I collagen (ICTP) were determined before and during IGF-I administration. Untreated patients with LS had lower than normal serum levels of PICP and PIIINP for age. IGF-I treatment increased significantly the PIIINP levels in children from 7.2 +/- 2.8 (SD) to 12.5 +/- 2.2 micrograms/l (P < 0.001), and in adults from 2.7 +/- 1.0 to 8.4 +/- 3.6 micrograms/l (P < 0.001); serum PICP increased from 243 +/- 123 to 384 +/- 190 microgram...Continue Reading

Citations

Sep 29, 2001·Molecular Pathology : MP·Z Laron
Jan 20, 1999·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Z LaronA Silbergeld
Apr 30, 2005·Trends in Endocrinology and Metabolism : TEM·Michael B Ranke
Dec 13, 2000·The Journal of Pediatrics·J A YanovskiN G Sebring
Mar 1, 2018·Frontiers in Endocrinology·Farhad DehkhodaAndrew J Brooks
Nov 16, 2017·European Journal of Endocrinology·Neha BahlVita Birzniece
Aug 31, 2007·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Hiroyasu YamamotoSoji Kasayama

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