PMID: 9448318Mar 14, 1998Paper

Insulin-like growth factor I restores motor coordination in a rat model of cerebellar ataxia

Proceedings of the National Academy of Sciences of the United States of America
A M FernandezI Torres-Aleman

Abstract

We tested the potential of insulin-like growth factor I (IGF-I) to induce functional recovery in an animal model of cerebellar ataxia because this motor impairment is accompanied in humans and rodents by distinct changes in several components of the IGF-I trophic system. Rats rendered ataxic by deafferentation of the cerebellar cortex with 3-acetylpyridine recovered motor function after IGF-I was administered, as determined by behavioral and electrophysiological tests. When treated with IGF-I, inferior olive neurons, the targets of the neurotoxin, were rescued to various degrees (from 92 to 27% of surviving neurons), depending on the time that treatment with IGF-I was initiated. Furthermore, full recovery was obtained regardless of the route by which the trophic factor was administered (intraventricular or subcutaneous) even in rats with severe neuronal loss. These results suggest that human ataxia could be treated with IGF-I by a simple procedure.

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Citations

Nov 30, 2000·Current Treatment Options in Neurology·S L Perlman
Feb 21, 2008·Neuromolecular Medicine·M Llorens-MartínJosé L Trejo
May 23, 2009·The Cerebellum·Kenji Akita, Shigeyuki Arai
Dec 31, 2003·Molecular and Cellular Neurosciences·E Garcia-GallowayI Torres-Aleman
Apr 12, 2002·Brain Research. Developmental Brain Research·Michelle F AndersonPeter S Eriksson
Mar 16, 2000·Trends in Neurosciences·H D VentersK W Kelley
Sep 6, 2002·Neuroscience Letters·Yoon Hee ChungChoong Ik Cha
Sep 7, 2000·Neuroscience·G P Cardona-GómezL M Garcia-Segura
Mar 22, 2007·Molecular Therapy : the Journal of the American Society of Gene Therapy·Filip LimJavier Díaz-Nido
Nov 1, 2003·Journal of Neurotrauma·Nico L U Van MeeterenFrank P T Hamers
Sep 17, 2004·Neuroreport·Carole EscartinEmmanuel Brouillet
Oct 9, 2012·Molecular Neurodegeneration·Carolina FrancoIgnacio Torres-Alemán
Jan 19, 2008·Sports Medicine·Lesley J White, Vanessa Castellano
Feb 2, 2011·Clinical Practice and Epidemiology in Mental Health : CP & EMH·Ingo HelmichHenning Budde
May 3, 2014·Neuroreport·Hiroko KotajimaDai Yanagihara
Nov 28, 2013·Behavioural Brain Research·Daria CameraPhilip Poronnik
Oct 23, 2014·International Journal of Molecular Sciences·Lucía Calatrava-FerrerasEulalia Bazán
Jun 24, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Xiang YiAlexander V Kabanov
Feb 24, 2007·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·S FernandezI Torres-Aleman
Mar 8, 2006·The European Journal of Neuroscience·Guido C KoopmansFrank P T Hamers
Apr 21, 2011·Movement Disorders : Official Journal of the Movement Disorder Society·Jonas Alex Morales SauteLaura Bannach Jardim
Apr 25, 2006·Journal of Diabetes and Its Complications·Gail M SeigelDouglas N Ishii

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