Insulin-like growth factor-I restores the reduced somatostatinergic tone controlling growth hormone secretion in cirrhotic rats

Liver
I Castilla-CortazarJ Prieto

Abstract

An altered growth hormone/insulin-like growth factor-I (GH/IGF-I) axis occurs in advanced liver cirrhosis, characterised by diminished serum levels of IGF-I and increased concentrations of GH. Under normal conditions, GH release is mediated by somatostatin (SS) inhibition. However, the influence of SS on GH release in cirrhosis is not well known. IGF-I supplementation has beneficial effects in experimental cirrhosis, and - under physiological conditions - IGF-I increases SS, inhibiting GH. The aims of this work were to study SS tone in cirrhotic animals and to evaluate whether IGF-I treatment influences SS tone, controlling GH secretion in cirrhosis. We studied the influence of SS on GH secretion by assessing GH response to pyridostigmine (PD) in cirrhotic rats treated and untreated with IGF-I. Liver cirrhosis was induced with CCl4-inhalation for 11 weeks in male Wistar rats. The animals were randomly divided into two groups: CI+IGF (n=12), which received IGF-I treatment for 12 days (2 microg/100 g body wt-1 x d-1) and CI (n=12), which received saline. Healthy controls (CO, n=12) were studied at the same time. On day 13, animals from each group were subdivided into two groups (n=6) in order to explore the effect of a PD intraju...Continue Reading

References

Apr 1, 1991·Journal of Endocrinological Investigation·A CaufriezG Copinschi
May 1, 1991·The Journal of Clinical Endocrinology and Metabolism·M Kelijman, L A Frohman
Sep 1, 1980·Endocrinology·V PurohitR A Vigersky
Nov 1, 1980·Endocrinology·R J MajeskaG A Rodan
Mar 1, 1995·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A DonaghyR Williams
Jan 1, 1995·European Journal of Endocrinology·J BertheratJ Epelbaum
Apr 16, 1998·Journal of Hepatology·A CemborainJ Prieto
Mar 8, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·I Castilla-CortazarJ Prieto
Jun 24, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·I Castilla-CortazarJ Prieto

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Citations

Mar 5, 2005·BMC Gastroenterology·María García-FernándezSalvador González-Barón
Nov 15, 2012·Journal of Translational Medicine·Juan E Puche, Inma Castilla-Cortázar
Oct 29, 2013·Journal of Translational Medicine·Lucia Guerra-MenéndezInma Castilla-Cortázar
May 8, 2008·World Journal of Gastroenterology : WJG·Raquel PérezInma Castilla-Cortázar
Jan 14, 2005·European Journal of Gastroenterology & Hepatology·Jian-Fen YangJian-Ming Han
Jan 7, 2016·Journal of Translational Medicine·G A AguirreI Castilla-Cortazar
Jun 12, 2008·Liver International : Official Journal of the International Association for the Study of the Liver·Federico TutauInma Castilla-Cortázar
Jan 27, 2017·Journal of Physiology and Biochemistry·V J Lara-DiazU Muñoz
Aug 10, 2004·World Journal of Gastroenterology : WJG·Inma Castilla-CortazarSalvador Gonzalez-Baron
May 6, 2017·Journal of Translational Medicine·Luis A Morales-GarzaInma Castilla-Cortazar
Feb 13, 2020·Journal of Translational Medicine·Inma Castilla-CortázarLuis Espinosa
Aug 17, 2004·World Journal of Gastroenterology : WJG·Yun-Lin WuRong-Ping Xi

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